Naslov
Primjena normobarične hiperoksije u neuroanesteziji
(Normobaric hyperoxia in neuroanesthesia)

Autori
Miklić Bublić, Martina ; Matas, Marijana ; Sekulić, Ante

Izvornik
Acta medica Croatica (1330-0164) 72 (2018), 1; 55-60

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hyperoxic lung injury ; Neuroanesthesia ; Neurosurgery ; Normobaric hyperoxia ; Pneumocephalus ; Stroke ; Traumatic brain injury

Sažetak
Normobaric hyperoxia is occasionally mentioned in the literature concerning neurosurgical anesthesia. Opinions vary on this subject. Hyperoxia was long related to the potentially harmful influence of reactive oxygen species that are produced during hyperoxia in the amounts greater than the antioxidant capacity, thus causing hyperoxic acute lung injury. Recent research shows that hyperoxia may be beneficial in treating traumatic brain injury. The main goals in neuroanesthesia are maintaining intracranial pressure and cerebral perfusion pressure while preventing secondary brain injury. Hyperoxia enhances brain tissue oxygenation and brain aerobic metabolism, thus being neuroprotective. Additional benefi t of hyperoxia may be found in the treatment of postoperative pneumocephalus by diminishing postoperative nausea and vomiting, and reducing the incidence of surgical site infections and facilitating their healing, thus providing better patient recovery. Considering the potential benefits of normobaric hyperoxia and its possible detrimental effect, additional investigation is needed to clearly define the patient category where hyperoxia may have positive effect on patient outcome.

Izvorni jezik
Hrvatski, engleski

POVEZANOST RADA