Naslov
Patch testing with methylchloroisothiazolinone/methylisothiazolinone using a new diagnostic mix - a multicenter study from the international contact dermatitis research group
(Patch testing with methylchloroisothiazolinone/methylisothiazolinone using a new diagnostic mix - a multicenter study from the international contact dermatitis research group)

Autori
Isaksson, Marléne ; Andersen, Klaus E ; Cannavó, Alicia ; Elsner, Peter ; Goh, Chee-Leok ; Gonçalo, Margarida ; Goossens, An ; Ljubojević Hadžavdić, Suzana ; Pratt, Melanie ; Puangpet, Pailin ; Sasseville, Denis ; Verma , Kaushal ; Bruze, Magnus

Izvornik
Dermatitis (1710-3568) 32 (2021), 4; 220-224

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
multicenter study ; patch testing ; methylchloroisothiazolinone ; new diagnostic mix

Sažetak
Background: In the early 1980s, a preservative containing a mixture of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) in a ratio of 3:1 was introduced. This mixture (mix) has been patch tested at 100 ppm (0.01%) worldwide and at 200 ppm (0.02%) in Sweden since 1986 and also in the European baseline series since 2014. Objective: A new aqueous mix of MCI 0.015% and MI 0.2% was compared with patch testing with the 2 aqueous baseline preparations of MCI/MI 0.02% and MI 0.2%. Methods: Four thousand three hundred ninety-seven patients with dermatitis in 12 International Contact Dermatitis Research Group dermatology departments from 3 continents were patch tested simultaneously with the 3 preparations. Results: The frequency of positive patch tests to the allergens varied between 0% and 26.7% in the 12 test centers. The new mixture MCI/MI 0.215% in aqua (aq) detected significantly more patients with MCI/MI allergy than both MCI/MI 0.02% aq (P < 0.001) and MI 0.2% aq (P < 0.001) alone and combined. Conclusions: The results favor replacing the preparations MCI/MI 0.02% aq and MI 0.2% aq with the mixture MCI/MI 0.215% aq in the International Contact Dermatitis Research Group baseline series.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA