Naslov
Unusual case of granuloma annulare associated with diabetes mellitus

Autori
Patrun, Stjepan ; Ljubojević Hadžavdić, Suzana

Izvornik
Acta Dermatovenerologica Croatica (1330-027X) 28 (2020), 1; 45-46

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo uredniku, znanstveni

Ključne riječi
granuloma annulare ; clinical variants ; diabetes mellitus ; diagnosis, treatment

Sažetak
Granuloma annulare (GA) is an asymptomatic, chronic, and relatively common granulomatous skin condition which presents with annular papules usually slowly progressing into plaques on the extremities and the trunk. It usually presents with non-scaly, erythematous, annular plaques on the distal extremity. The pathogenesis of GA is still unknown, although a variety of possible factors contributing the disease have been reported, including drugs, insect bites, sun exposure, trauma, vaccinations, and viral infections. There are many clinical variants of GA such as localized, generalized, disseminated, subcutaneous, arcuate dermal erythema, and perforating GA. The localized form of GA is most common with annular plaques on the distal extremities. In addition to the typical lesions on the dorsal side of both hands, our patient also presented with atypical, circular lesions around her neck. The relationship between GA and systemic diseases such as diabetes mellitus, thyroid disorders, dyslipidemia, and malignancies remains unclear. It is also uncertain whether genetic factors influence susceptibility to GA. GA is a common idiopathic disorder of the dermis and subcutaneous tissue that can be associated with a variety of underlying conditions such as diabetes mellitus. The relationship between GA and diabetes mellitus is still unknown. Since skin lesions preceded the diagnosis of DM in our patient and complete remission of skin changes occurred with induction of insulin therapy, it is important to perform routine laboratory test in every patient.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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