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Pregled bibliografske jedinice broj: 1197567

A refined topography of the HLA molecular landscape across populations

Nunes, José Manuel; Di, Da; Gerbault, Pascale; Faye, Ndeye K.; Almawi, Wassim; Andreani, Marco; Arrieta-Bolanos, Esteban; Díaz Peña, Roberto; D'Silva, Selma; Dubois, Valérie et al.
A refined topography of the HLA molecular landscape across populations // 36th European Immunogenetics and Histocompatibility Conference / Marsh, Steven G. E. (ur.).
Amsterdam, Nizozemska: John Wiley & Sons, 2022. str. 416-550 doi:10.1111/tan.14606 (predavanje, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 1197567 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
A refined topography of the HLA molecular landscape across populations

Autori
Nunes, José Manuel ; Di, Da ; Gerbault, Pascale ; Faye, Ndeye K. ; Almawi, Wassim ; Andreani, Marco ; Arrieta-Bolanos, Esteban ; Díaz Peña, Roberto ; D'Silva, Selma ; Dubois, Valérie ; Eltayeb, Gehad Elghazali ; Gorodezky, Clara ; Grubic, Zorana ; Hajeer, Ali ; Ivanova, Milena ; Jha, Aashish ; Kanga, Uma ; Kirijas, Meri ; Lemieux, William ; Lenz, Tobias ; Loginova, Maria ; Mahfoudh, Nadia ; Mehra, Narinder ; Petrek, Martin ; Richard, Lucie ; Roelen, Dave L. ; Sacchi, Nicoletta ; Singh, Bisu ; Singh, Meenakshi ; Tarassi, Katerina ; Vangenot, Christelle ; Vidan-Jeras, Blanka ; Vigilant, Linda ; Wroblewski, Emily ; Buhler, Stéphane ; Villard, Jean ; De Groot, Natasja ; Sanchez-Mazas, Alicia

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
36th European Immunogenetics and Histocompatibility Conference

Mjesto i datum
Amsterdam, Nizozemska, 17.05.2022. - 20.05.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HLA, molecular landscape, populations

Sažetak
A fine characterization of the HLA molecular profiles of populations from distinct origins and ethnical back-grounds is essential for both clinical issues in histocompatibility and transplantation and fundamental research in population and evolutionary genetics. Recent developments of high throughput sequencing technologies(including NGS) have allowed generating high resolution data at most HLA loci for thousands of individuals at rather accessible costs, leading many laboratories to type or retype large population samples with the aim to fill gaps in the landscape of HLA-typed populations, thereby significantly improving the quality of the molecular data available. Under the umbrella of the EFI Population Genetics Working Group and the Population Genetics, Anthropology and Evolution (PGAE) Component of the 18th International HLA & Immunogenetics Workshop, as many as 30 laboratories were involved in a collective effort to improve the HLA molecular map of a large geographic region encompassing Europe, North Africa, West Asia and South Asia and also including populations of European and mixed descent from North, Central and South America. In addition to 15populations represented by very large samples (in total more than 270, 000 individuals) typed at the 2nd-fieldlevel of resolution, the final dataset includes20 populations sequenced by NGS and reported at the4th-field level for up to 11 HLA loci. Statistical and graphical analyses of this newly generated dataset, combined with previously available worldwide data, reveal a much more precise topography of the HLA molecular landscape across populations and hence also improve the reference datasets used in histocompatibility and transplantation. The observed HLA molecular diversity is further contrasted to that of equivalent MHC-Patr loci analyzed in several chimpanzee cohorts (with implementation of new sequence data), enabling novel interpretations of the genetic history and evolution of the secrucial immune genes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Ustanove:
Klinički bolnički centar Zagreb

Profili:

Avatar Url Zorana Grubić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Nunes, José Manuel; Di, Da; Gerbault, Pascale; Faye, Ndeye K.; Almawi, Wassim; Andreani, Marco; Arrieta-Bolanos, Esteban; Díaz Peña, Roberto; D'Silva, Selma; Dubois, Valérie et al.
A refined topography of the HLA molecular landscape across populations // 36th European Immunogenetics and Histocompatibility Conference / Marsh, Steven G. E. (ur.).
Amsterdam, Nizozemska: John Wiley & Sons, 2022. str. 416-550 doi:10.1111/tan.14606 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Nunes, J., Di, D., Gerbault, P., Faye, N., Almawi, W., Andreani, M., Arrieta-Bolanos, E., Díaz Peña, R., D'Silva, S. & Dubois, V. (2022) A refined topography of the HLA molecular landscape across populations. U: Marsh, S. (ur.)36th European Immunogenetics and Histocompatibility Conference doi:10.1111/tan.14606.
@article{article, author = {Nunes, Jos\'{e} Manuel and Di, Da and Gerbault, Pascale and Faye, Ndeye K. and Almawi, Wassim and Andreani, Marco and Arrieta-Bolanos, Esteban and D\'{\i}az Pe\~{n}a, Roberto and D'Silva, Selma and Dubois, Val\'{e}rie and Eltayeb, Gehad Elghazali and Gorodezky, Clara and Grubic, Zorana and Hajeer, Ali and Ivanova, Milena and Jha, Aashish and Kanga, Uma and Kirijas, Meri and Lemieux, William and Lenz, Tobias and Loginova, Maria and Mahfoudh, Nadia and Mehra, Narinder and Petrek, Martin and Richard, Lucie and Roelen, Dave L. and Sacchi, Nicoletta and Singh, Bisu and Singh, Meenakshi and Tarassi, Katerina and Vangenot, Christelle and Vidan-Jeras, Blanka and Vigilant, Linda and Wroblewski, Emily and Buhler, St\'{e}phane and Villard, Jean and De Groot, Natasja and Sanchez-Mazas, Alicia}, editor = {Marsh, S.}, year = {2022}, pages = {416-550}, DOI = {10.1111/tan.14606}, keywords = {HLA, molecular landscape, populations}, doi = {10.1111/tan.14606}, title = {A refined topography of the HLA molecular landscape across populations}, keyword = {HLA, molecular landscape, populations}, publisher = {John Wiley and Sons}, publisherplace = {Amsterdam, Nizozemska} }
@article{article, author = {Nunes, Jos\'{e} Manuel and Di, Da and Gerbault, Pascale and Faye, Ndeye K. and Almawi, Wassim and Andreani, Marco and Arrieta-Bolanos, Esteban and D\'{\i}az Pe\~{n}a, Roberto and D'Silva, Selma and Dubois, Val\'{e}rie and Eltayeb, Gehad Elghazali and Gorodezky, Clara and Grubic, Zorana and Hajeer, Ali and Ivanova, Milena and Jha, Aashish and Kanga, Uma and Kirijas, Meri and Lemieux, William and Lenz, Tobias and Loginova, Maria and Mahfoudh, Nadia and Mehra, Narinder and Petrek, Martin and Richard, Lucie and Roelen, Dave L. and Sacchi, Nicoletta and Singh, Bisu and Singh, Meenakshi and Tarassi, Katerina and Vangenot, Christelle and Vidan-Jeras, Blanka and Vigilant, Linda and Wroblewski, Emily and Buhler, St\'{e}phane and Villard, Jean and De Groot, Natasja and Sanchez-Mazas, Alicia}, editor = {Marsh, S.}, year = {2022}, pages = {416-550}, DOI = {10.1111/tan.14606}, keywords = {HLA, molecular landscape, populations}, doi = {10.1111/tan.14606}, title = {A refined topography of the HLA molecular landscape across populations}, keyword = {HLA, molecular landscape, populations}, publisher = {John Wiley and Sons}, publisherplace = {Amsterdam, Nizozemska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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