Naslov
Atrial fibrillation in heart failure with preserved ejection fraction - the PARAGON-HF trial

Autori
Čikes, Maja ; Planinc, Ivo ; Claggett, Brian ; Cunningham, Jonathan ; Milicic, Davor ; Sweitzer, Nancy ; Senni, Michele ; Gori, Mauro ; Linssen, Gerard ; Shah, Sanjiv J. ; Packer, Milton ; Pfeffer, Marc ; Zile, Michael R. ; Anand, Inder ; Chiang, Lu-May ; Lam, Carolyn S.P. ; Redfield, Margaret ; Desai, Akshay S. ; McMurray, John J.V. ; Solomon, Scott D.

Izvornik
JACC. Heart failure (2213-1779) 10 (2022), 5; 336-346

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
atrial fibrillation ; echocardiography ; heart failure outcomes ; heart failure with preserved ejection fraction ; sacubitril/valsartan

Sažetak
Background: Atrial fibrillation and flutter (AFF) are common in heart failure with preserved ejection fraction (HFpEF) and increase the risk of adverse outcomes. Methods: A total of 4, 776 patients formed 3 groups: those with AFF according to electrocardiography (ECG) at enrollment (n = 1, 552 ; 33%), those with history of AFF but without AFF on ECG at enrollment (n = 1, 005 ; 21%), and those without history of AFF or AFF on ECG at enrollment (n = 2, 219, 46%). We assessed outcomes, treatment response to sacubitril/valsartan in each group, and the risk associated with first-detected AFF in patients without any known AFF. The primary outcome was a composite of total heart failure hospitalizations and cardiovascular death. Results: History of AFF and AFF at enrollment were associated with higher risk of the primary outcome (risk ratio [RR]: 1.36 [95% CI: 1.12-1.65] and RR: 1.31 [1.11- 1.54], respectively), than no AFF. Neither history of AFF nor AFF at enrollment modified the treatment effect of sacubitril/valsartan. Post randomization AFF occurred in 12% of patients without previous AFF and was associated with 2.8-fold higher risk of the primary outcome, but it was not influenced by sacubitril/valsartan. Conclusions: History of AFF and AFF on ECG at enrollment were associated with a higher risk of the primary outcome. First-detected AFF was not influenced by sacubitril/valsartan, yet it was associated with increased risk of all subsequent outcomes and may represent a potential target for future HFpEF trials. (Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction [PARAGON-HF] ; NCT01920711).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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