Association of the autoantibodies to M-typephospholipase A2 receptor titer with clinicalcharacteristics and outcome of patientswith primary membranous nephropathy– 5-year follow up study

Laganović, Mario; Horvatić, Ivica; Bubić, Ivan; Ilić, Mario; Maksimović, Bojana; Kozmar Ana; Vuković Brinar, Ivana; Crnogorac, Matija; Živko, Marijana; Fištrek, Margareta; Jureković, Željka, Galešić Ljubanović, Danica; Ćorić, Marijana; Bulimbašić, Stela; Galešić, Krešimir; Knotek, Mladen

doi:10.20471/acc.2021.60.s1.11

Pregled bibliografske jedinice broj: 1197308

Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study

Laganović, Mario; Horvatić, Ivica; Bubić, Ivan; Ilić, Mario; Maksimović, Bojana; Kozmar Ana; Vuković Brinar, Ivana; Crnogorac, Matija; Živko, Marijana; Fištrek, Margareta et al.

Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study // Acta clinica Croatica. Supplement, 60 (2021), 1; 71-77 doi:10.20471/acc.2021.60.s1.11 (domaća recenzija, članak, znanstveni)

CROSBI ID: 1197308 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of the autoantibodies to M-type phospholipase A2 receptor titer with clinical characteristics and outcome of patients with primary membranous nephropathy – 5-year follow up study

Autori
Laganović, Mario ; Horvatić, Ivica ; Bubić, Ivan ; Ilić, Mario ; Maksimović, Bojana ; Kozmar Ana ; Vuković Brinar, Ivana ; Crnogorac, Matija ; Živko, Marijana ; Fištrek, Margareta ; Jureković, Željka, Galešić Ljubanović, Danica ; Ćorić, Marijana ; Bulimbašić, Stela ; Galešić, Krešimir ; Knotek, Mladen

Izvornik
Acta clinica Croatica. Supplement (0353-9474) 60 (2021), 1; 71-77

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
membranous nephropathy ; M-type phospholipase A2 receptor ; autoantibodies ; glomerulonephritis

Sažetak
Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB). This study aimed to evaluate the clinical course and outcomes of the patients with pMN regarding PLA2R-AB status. Patients and methods: 32 patients (21 males, 11 females) with renal biopsy-proven pMN were included in the study. PLA2R-AB (ELISA method) and outcomes (defined according to KDIGO) were evaluated after 21 and 64 months of follow-up in 28 patients. Results: 19 patients had positive PLA2R-AB (>20 RU/ml) (59.3%), with median titer of 97 (21-1418 RU/ml). The rate of remission in low PLA2R-AB titer group (< 200 RU/ml) after 21 months was significantly higher than in high PLA2R-AB group (> 200 RU/ml) (90% vs. 50%, p=0.045), and after 64 months the difference was not significant (80% vs. 50%, p=0.210). The relapse rate after 64 months was higher in the high PLA2R- AB group (87% vs. 63%). Multivariant linear regression found serum creatinine (ß=0.682, p<0.001) and PLA2R-AB (ß=0.527, p<0.001) as significant predictors for kidney function at the end of follow-up. Conclusion: higher titers of PLA2R-AB are related to worse kidney function outcome, higher 24-hour proteinuria, and a higher number of relapses in patients with pMN.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Ustanove:
Klinička bolnica "Merkur",
Medicinski fakultet, Rijeka,
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek,
Klinički bolnički centar Rijeka,
Opća bolnica Dubrovnik

Profili:

Ivan Bubić (autor)