Naslov
Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices: insights from TRAViATA

Autori
Darden, Douglas ; Ammirati, Enrico ; Brambatti, Michela ; Lin, Andrew ; Hsu, Jonathan C. ; Shah, Palak ; Perna, Enrico ; Čikeš, Maja ; Gjesdal, Grunde ; Potena, Luciano ; Masetti, Marco ; Jakuš, Nina ; Van De Heyning, Caroline ; De Bock, Dina ; Brugts, Jasper J. ; Russo, Claudio F. ; Veenis, Jesse F. ; Rega, Filip ; Cipriani, Manlio ; Frigerio, Maria ; Liviu, Klein ; Hong, Kimberly N. ; Adler, Eric ; Braun, Oscar Ö.

Izvornik
International journal of cardiology (0167-5273) 340 (2021); 26-33

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cardiac resynchronization therapy ; heart failure ; implantable cardiac defibrillator ; left ventricular assist device ; mortality ; right ventricular failure

Sažetak
Background: There is conflicting observational data on the survival benefit cardiac implantable electronic devices (CIED) in patients with LVADs. Methods: Patients in whom an LVAD was implanted between January 2008 and April 2017 in the multinational Trans-Atlantic Registry on VAD and Transplant (TRAViATA) registry were separated into four groups based on the presence of CIED prior to LVAD implantation: none (n = 146), implantable cardiac defibrillator (ICD) (n = 239), cardiac resynchronization without defibrillator (CRT-P) (n = 28), and CRT with defibrillator (CRT-D) (n = 111). Results: A total of 524 patients (age 52 years ±12, 84.4% male) were followed for 354 (interquartile range: 166-701) days. After multivariable adjustment, there were no differences in survival across the groups. In comparison to no device, only CRT-D was associated with late right ventricular failure (RVF) (hazard ratio 2.85, 95% confidence interval [CI] 1.42- 5.72, p = 0.003). There was no difference in risk of early RVF across the groups or risk of ICD shocks between those with ICD and CRT-D. Conclusion: In a multinational registry of patients with LVADs, there were no differences in survival with respect to CIED subtype. However, patients with a pre-existing CRT-D had a higher likelihood of late RVF suggesting significant long-term morbidity in those with devices capable of LV‑lead pacing post LVAD implantation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA