Naslov
Lymphocytic adenohypophysitis simulating pituitary adenoma

Autori
Talan-Hranilović, J. ; Čupić, H. ; Gnjidić, Ž. ; Hat, J.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
9th LJUDEVIT JURAK INTERNATIONAL SYMPOSIUM ON COMPARATIVE PATHOLOGY BOOK OF ABSTRACTS / Talan Hranilović, Jasna ; Lechpammer, Mirna - Zagreb, 1998

Skup
9th LJUDEVIT JURAK INTERNATIONAL SYMPOSIUM ON COMPARATIVE PATHOLOGY

Mjesto i datum
Zagreb, Hrvatska, 05.06.1998. - 06.06.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
pituitary adenoma; Lymphocytic adenohypophysitis

Sažetak
Lymphocytic adenohypophysitis (LAH) is a rare autoimmune inflammatory process ofthe pituitary gland occurring predominantly during the peripartal period. LAH can cause pituitary expansion and hypopituitarism presenting with features suggestive of a pituitary adenoma.We report a case of a 39-year-old woman who developed bitemporal hemianopsia and artralgic pain in the small joints during the late stage of her second pregnancy. Five months after the delivery visual field defects withdrew, but serum hormone analysis revealed hypothyroidism and increased levels of PRL. Magnetic resonance imaging showed an intrasellar mass with suprasellar extension measuring I 6x I 2mm, that closely resembled pituitary adenoma. A transphenoidal approach was used to remove the patients' sellar lesion and all of the abnormal tissue was removed. Histopathological examination of the tumor showed an extensive mononuclear infiltration of the adenohypophysis tissue by plasma cells and lymphocytes forming follicles with germinal centers. Neurohypophysis was uninvolved, morphologically normaLThe immunoperoxidase technique showed difFuse presence of immunoreactive prolactin within surviving adenohypophysal cells. Immunohistochemistry revealed CD3 and CD8 positiveT cells at the periphery of lymphatic follicles and in the interfollicular areas. CD 20 positivity was observed in the follicular centers. Diffuse positivity for CD45 was observed throughout the lesion. Our data suggest that the disorder is related to cell-mediated immunity as well as humoral immunity.The question of surgical treatment, of this rare pathological entity, still remains open.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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