Naslov
Predictive power of KI 67 antigen expression in uveal melanomas

Autori
Krvavica, Ana ; Talan-Hranilović, Jasna ; Belicza, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
10t Ljudevit Jurak international symposium on comparative pathology : book of abstracts / Talan Hranilović, Jasna ; Krušlin, Božo - Zagreb, 1999

Skup
Ljudevit Jurak international symposium on comparative pathology (10 ; 1999)

Mjesto i datum
Zagreb, Hrvatska, 04.06.1999. - 05.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
KI 67 antigen; melanomas

Sažetak
Uveal melanomas are made of two distinctive cell types, spindle and epitheloid, with differing clinical implications. These melanomas are known to be less aggre-ssive malignant tumours comparing to the cutaneous type of same cell characteristic (1). The intent of this short study was to investigate expression of Ki-67 immunocomplex in uveal melanoma cells, examine if intensity of expression correlates with levels of invasion, which would result in prognostic significance. 19 uveal melanomas were tested for the presence of Ki-67 protein by indirect peroxidase antiperoxidase method and monodonal antibody for Ki-67 protein. The intensity of the reaction is marked by a semi-quantative method. All samples of epitheloid melanomas showed strongly positive Ki-67 reaction. Spindle B cells, which are a transi-tional type between epitheloid and spindle A cells, show greater variation in Ki-67 expression, from negative to moderately positive.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA