Naslov
Neutral effect of Glioma-associated oncogene-1 expression on survival in myelofibrosis

Autori
Lucijanic M, Livun A, Tupek KM, Stoos-Veic T, Pejsa V, Jonjic Z, Dzankic AF, Ivic M, Kusec R.

Izvornik
Wiener klinische Wochenschrift (0043-5325) 15 (2020); 464-466

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Philadelphia negative myeloproliferative neoplasm · Bone marrow fibrosis · Sonic Hedgehog ·
(Philadelphia negative myeloproliferative neoplasm · Bone marrow fibrosis · Sonic Hedgehog · Smoothened)

Sažetak
This study retrospectively analyzed gliomaassociated oncogene 1 (GLI-1) mRNA expression in unfractionated bone marrow aspirates of 32 patients with myelofibrosis and 16 controls. It was found that GLI-1 expression did not significantly differ between primary, secondary myelofibrosis and controls (median difference in threshold cycles ΔCT 7.2, 7.3 and 6.9, respectively ; P= 0.864), as well as that survival curves of myelofibrosis patients with higher/lower GLI-1 expression showed multiple overlaps and overall comparable course (P= 0.651). The results suggest that general upregulation of GLI-1 does not seem to be a feature of the disease and are in line with modest biological and clinical effects observed with inhibitors of Hedgehog signaling pathway in patients with myelofibrosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA