Naslov
White wine—induced endothelium-dependent vasorelaxation in Sprague-Dawley rats

Autori
Mihaljević, Zrinka ; Kujundžić, Toni ; Jukić, Vladimir ; Stupin, Ana ; Drenjančević, Mato ; Drenjančević, Ines

Izvornik
Antioxidants (2076-3921) 11 (2022), 5; 1-17

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
vasodilation ; wine ; Sprague-Dawley rat ; antioxidants ; fermentation

Sažetak
Abstract:The vasodilatory activity and polyphenolic content of commercially available white wine islow compared to red wines. This study assessed the vasodilator potential of white wines produced byfour different fermentation processes: (1) white wine produced by the standard procedure ; (2) grapesleft to macerate completely for 30 days ; (3) grapes left to macerate up to half of unfermented sugar ; and (4) wine produced by cooling the must. All tested wine samples were analyzed for their phenoliccontent, antioxidant capacity, and ethanol content. Vasodilation was examined in the norepinephrinepre-contracted isolated rat aortas of male Sprague-Dawley rats randomly exposed to cumulativeconcentrations (0.1‰to 8‰final dilutions in organ baths) of each of the tested wine samples withor without quercetin and/or gallic acid supplementation, in the absence/presence of NOS inhibitorL-NAME. Standard procedure and the procedure involving must cooling gives wine with lowerphenolic content, antioxidant capacity, and lower vasodilator potential, respectively. L- NAMEinhibited vasodilation to all wine samples. Quercetin with or without gallic acid supplementationrestored vasodilation. Results show that vasodilation to white wine is NO-dependent and suggestthe possibility of increasing the antioxidant capacity and vasodilatory potential of white wine usingdifferent production procedures, depending on quercetin content.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Prehrambena tehnologija, Nutricionizam, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA