Naslov
Clinical characteristics and treatment of lupus nephritis – preliminary analysis of observational data from a National Referral Centre

Autori
Knežević, Tamara ; Padjen, Ivan ; Bulimbašić, Stela ; Ćorić, Marijana ; Ivković, Vanja ; Laganović, Mario ; Anić, Branimir

Izvornik
Acta clinica Croatica. Supplement (0353-9474) 60 (2021), 1; 155-163

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
systemic lupus erythematosus ; lupus nephritis ; treatment ; population characteristics

Sažetak
Lupus nephritis (LN) is one of the most severe features of systemic lupus erythe- matosus (SLE). Data on LN is scarce in the Croatian population. We analysed the characteristics of LN patients diagnosed at our tertiary referral centre. In this retrospective study, we analysed the fol- lowing features of patients with biopsy-proven LN diagnosed between 2011 and 2020: demographics, renal laboratory parameters, renal histopathology, and treatment. A total of 38 patients were included (30 females ; mean age 39±15 years). The most common indi- cation for kidney biopsy was proteinuria (89%). The proportion of LN classes was: class I (2.6%), II (5.3%), III (18.4%), IV (42.1%), V (13.2%), III+V (10.5%), IV+V (5.3%). The median time from SLE diagnosis to histologic confirmation of LN was 1.0 year. All patients were treated with methylpred- nisolone (MP), 68% received MP pulses. Induction treatment included intravenous (IV) cyclophos- phamide (CYC) (71%) (15 patients treated per Euro-Lupus and 9 per the National Institutes of Health regimen), oral CYC (3%), or mycophenolate mofetil (11%). 79% of patients received antima- larials. While there is heterogeneity between different populations, our patient profile was similar to that from other European studies. Further follow-up of this group is necessary to assess outcomes in our population.

Izvorni jezik
Hrvatski

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