Naslov
SECONDARY BRAIN TUMORS AFTER THERAPY OF ACUTE LYMPHOBLASTIC LEUKEMIE

Autori
Hajnić, T. F. ; Mataija, M. ; Talan-Hranilović, Jasna ; Cvitanović, LJ. ; Mučić, B.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
10TH LJUDEVIT JURAK INTERNATIONAL SYMPOSIUM ON COMPARATIVE PATHOLOGY BOOK OF ABSTRACTS / Talan Hranilović, Jasna ; Kruslin, Božo - Zagreb, 1999

Skup
10TH LJUDEVIT JURAK INTERNATIONAL SYMPOSIUM ON COMPARATIVE PATHOLOGY

Mjesto i datum
Zagreb, Hrvatska, 04.06.1999. - 05.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
SECONDARY BRAIN TUMORS; LYMPHOBLASTIC LEUKEMIE

Sažetak
Acute leukaemia is the most frequent malignant disease in children . Primarily cells can infiltrate any organ, and one of the favourable sites is brain. In order to prevent blastic infiltration of the brain, primarily in ALL, almost all of the previous protocols for curing ALL included preventive irradiation of brain in addition to combined chemotherapy. Today it is well known that aggressive polychemotherapy and irradiation of hemoblastosis and solid tumours, can cause the development of other forms of malignant diseases after 5 to 30 years. Aim Three patients who were radiated with 2, 5 Gy during the treatment of ALL according to the previous protocols, developed secondary malignoms of the brain otherwise very rare in childhood - neuroblastoma, meningeoma and non Hodkgin lymphoma, during the period of 5 to 10 years following irradiation. Patients I ALL was diagnosed at the age of 3, and treated by modified Pinkel protocol. In addition to MTX taken intrathecal irradiation of the brain was performed with 2, 4 Gy. Ten years after irradiation, neurologic deficits developed and CT revealed a tumour of the frontoparietal area. PHD: neuroblastoma. The patient died after two recidives (therapy: operation, polychemotherapy, and irradiation). II ALL was diagnosed at the age of 8 months and treated according to the YU 84 protocol in combination with irradiation with 2, 5 Gy. Ten years after the therapy was completed the neurologic deficits developed, clinical observation discovered a greater tumour process in the left temporoparietal area. Ablation of the tumour process, PHD: meningeoma. Control analysis: no signs of recidive or residua of tumour process. III The third patient underwent irradiation of the brain with 2, 5 Gy in combination with oncologic treatment at the age of 3. Neurologic deficits developed 7 years after complete remission. Lumbal punction was performed and cytological analysis of liquor showed non-Hodkgin lymphoma, and CT proved a solitary process of the left hemisphere meningeal. Therapy was continued abroad. Conclusion In these three cases we have diagnosed otherwise very rare tumours of the brain in children. The diagnoses followed the treatment of ALL according to the complex protocol, which also included irradiation of the brain. Because of this potential complications the modern protocol of treatment of ALL excludes application of high irradiation doses to the brain. Considering the age and dose of irradiation, irradiation is used only in children older than one year of age and in doses of maximal 1, 2 Gy and only in the group of children with high risk and those with primarily infiltration of the brain.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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