Naslov
Kronična urtikarija: novosti u patogenezi i liječenju
(Chronic urticaria: update on the pathogensis and emerging treatments)

Autori
Peternel, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7. kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem / - , 2022

Skup
7. kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem

Mjesto i datum
Vodice, Hrvatska, 05.05.2022. - 08.05.2022

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
chronic urticaria ; angioedema ; omalizumab ; autoimmunity ; Bruton tyrosine kinase

Sažetak
Chronic spontaneous urticaria (CSU) is characterized by typically short-lived wheals, angioedema or both, which occur spontaneously and last longer than 6 weeks. This term is used for the most common form of chronic urticaria (CU). The annual prevalence of CU is 0.5% to 2.3%, and its lifetime prevalence is 1.8% across several countries in the United States and Europe. Omalizumab is the only currently approved treatment for antihistamine-refractory CSU, and additional and better treatments for CSU and other subtypes of CU are needed. Objective of the presentation is to provide an update on the pathogenesis of CSU and to discuss novel therapeutic agents that are under development for the treatment of CU/CSU. This update will cover recent findings on the pathogenesis of CSU regarding its two endotypes: type I autoimmune (or autoallergic) CSU, triggered by IgE to autoallergens, and type IIb autoimmune CSU, which is due to mast cell-directed autoantibodies. Several reports suggest that type I autoimmune and type IIb autoimmune CSU patients differ in their disease features, laboratory markers, and response to omalizumab treatment. Newer therapeutical agents are emerging that may offer additional alternatives to antihistamines and omalizumab for CU/CSU patients, including anti-IgE agents, anti-cytokine and anti-receptor biologics, and BTK inhibitors, which will be reviewed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA