Naslov
Obstructive sleep apnea and type 2 diabetes mellitus

Autori
Đermanović Dobrota, Vesna ; Lukinović-Škudar, Vesna ; Dobrota, Savko ; Filipović-Grčić, Luka ; Prkačin, Ingrid ; Hrabač, Pero ; Vrkić Kirhmajer, Majda ; Butković Soldo, Silva

Izvornik
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti (1330-5301) 547 (2021), 54-55; 76-85

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
sleep apnea ; obstructive sleep apnea ; sleep apnea syndrome ; diabetes mellitus

Sažetak
Obstructive sleep apnea (OSA) and type 2 diabetes mellitus (T2DM) are both common diseases that present a burden to a remarkable number of individuals worldwide, and their incidence and prevalence are constantly raising. OSA and T2DM coexist very often, they have common independent predisposing factors, and the main of them is obesity. However, they can share many other pathogenetic factors like chronic inflammation, oxidative stress, hormonal changes and autonomic nervous system disbalance, which are discussed in this review. OSA and T2DM, when untreated or undertreated, may lead to the additive or synergistic effect in a patient, leading to accelerated development of atherosclerosis and its cardiovascular complications. Recently, concomittant presence of OSA and T2DM was linked to possibility of higher incidence of colon cancer. As OSA, obesity and diabetes type 2 presen tindependent increased risk for cardiovascular complications, cardiovascular morbidity and mortality, special focus should be put on the early recognition of OSA simptoms in the patients with T2DM, and vice versa, patients with OSA should be regularly checked for presence of glucose intolerance or insulin resistance, in order to prevent longterm consequences.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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