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Pregled bibliografske jedinice broj: 1193932

The genetic basis of hepatosplenic T-cell lymphoma

Mc Kinney, M; Moffitt, AB; Gaulard, P; Travert, M; De Leval, L; Nicolae, A; Raffield, M; Jaffe, ES; Pittaluga, S; Xi, L et al.
The genetic basis of hepatosplenic T-cell lymphoma // Cancer Discovery, 7 (2017), 369-379 doi:10.1158/2159-8290.CD-16-0330 (međunarodna recenzija, članak, znanstveni)

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Naslov
The genetic basis of hepatosplenic T-cell lymphoma

Autori
Mc Kinney, M ; Moffitt, AB ; Gaulard, P ; Travert, M ; De Leval, L ; Nicolae, A ; Raffield, M ; Jaffe, ES ; Pittaluga, S ; Xi, L ; Hevaican, T ; Iqbal, J ; Belhadj, K ; Delfau-Larue, MH ; Fataccioli, V ; Czader, MB ; Lossos, IS ; Chapman-Fredericks, JR ; Richards, KL ; Fedoriw, Y ; Ondrejka, SL ; Hsi, ED ; Low, L ; Weisenburger, D ; Chan, WC ; Mehta-Shah, N ; Horwitz, S ; Bernal-Mizrachi, L ; Flowers, CR ; Beaven, AW ; Parihar, M ; Baseggio, L ; Parrens, M ; Moreau, A ; Sujobert, P ; Pilichowska, M ; Evens, AM ; Chadburn, A ; Au-Yeung, RKH ; Srivastava, G ; Choi, WWL ; Goodlad, JR ; Aurer, Igor ; Bašić-Kinda, Sandra ; Gascoyne, RD ; Davis, NS ; Li, G ; Zhang, J ; Rajagopalan, D ; Reddy, A ; Love, C ; Levy, S ; Zhuang, Y ; Datta, J ; Dunson, DB ; Dave, SS

Izvornik
Cancer Discovery (2159-8274) 7 (2017); 369-379

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hepatosplenic T-cell lymphoma

Sažetak
Hepatosplenic T-cell lymphoma (HSTL) is a rare and lethal lymphoma ; the genetic drivers of this disease are unknown. Through whole-exome sequencing of 68 HSTLs, we defi ne recurrently mutated driver genes and copy-number alterations in the disease. Chromatinmodifying genes, including SETD2, INO80, and ARID1B, were commonly mutated in HSTL, affecting 62% of cases. HSTLs manifest frequent mutations in STAT5B (31%), STAT3 (9%), and PIK3CD (9%), for which there currently exist potential targeted therapies. In addition, we noted less frequent events in E ZH2, KRAS , and T P53 . S ETD2 was the most frequently silenced gene in HSTL. We experimentally demonstrated that SETD2 acts as a tumor suppressor gene. In addition, we found that mutations in STAT5B and PIK3CD activate critical signaling pathways important to cell survival in HSTL. Our work thus defi nes the genetic landscape of HSTL and implicates gene mutations linked to HSTL pathogenesis and potential treatment targets. SIGNIFICANCE: We report the fi rst systematic application of whole-exome sequencing to defi ne the genetic basis of HSTL, a rare but lethal disease. Our work defi nes SETD2 as a tumor suppressor gene in HSTL and implicates genes including INO80 and PIK3CD in the disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Igor Aurer (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi

Citiraj ovu publikaciju:

Mc Kinney, M; Moffitt, AB; Gaulard, P; Travert, M; De Leval, L; Nicolae, A; Raffield, M; Jaffe, ES; Pittaluga, S; Xi, L et al.
The genetic basis of hepatosplenic T-cell lymphoma // Cancer Discovery, 7 (2017), 369-379 doi:10.1158/2159-8290.CD-16-0330 (međunarodna recenzija, članak, znanstveni)
Mc Kinney, M., Moffitt, A., Gaulard, P., Travert, M., De Leval, L., Nicolae, A., Raffield, M., Jaffe, E., Pittaluga, S. & Xi, L. (2017) The genetic basis of hepatosplenic T-cell lymphoma. Cancer Discovery, 7, 369-379 doi:10.1158/2159-8290.CD-16-0330.
@article{article, author = {Mc Kinney, M and Moffitt, AB and Gaulard, P and Travert, M and De Leval, L and Nicolae, A and Raffield, M and Jaffe, ES and Pittaluga, S and Xi, L and Hevaican, T and Iqbal, J and Belhadj, K and Delfau-Larue, MH and Fataccioli, V and Czader, MB and Lossos, IS and Chapman-Fredericks, JR and Richards, KL and Fedoriw, Y and Ondrejka, SL and Hsi, ED and Low, L and Weisenburger, D and Chan, WC and Mehta-Shah, N and Horwitz, S and Bernal-Mizrachi, L and Flowers, CR and Beaven, AW and Parihar, M and Baseggio, L and Parrens, M and Moreau, A and Sujobert, P and Pilichowska, M and Evens, AM and Chadburn, A and Au-Yeung, RKH and Srivastava, G and Choi, WWL and Goodlad, JR and Aurer, Igor and Ba\v{s}i\'{c}-Kinda, Sandra and Gascoyne, RD and Davis, NS and Li, G and Zhang, J and Rajagopalan, D and Reddy, A and Love, C and Levy, S and Zhuang, Y and Datta, J and Dunson, DB and Dave, SS}, year = {2017}, pages = {369-379}, DOI = {10.1158/2159-8290.CD-16-0330}, keywords = {hepatosplenic T-cell lymphoma}, journal = {Cancer Discovery}, doi = {10.1158/2159-8290.CD-16-0330}, volume = {7}, issn = {2159-8274}, title = {The genetic basis of hepatosplenic T-cell lymphoma}, keyword = {hepatosplenic T-cell lymphoma} }
@article{article, author = {Mc Kinney, M and Moffitt, AB and Gaulard, P and Travert, M and De Leval, L and Nicolae, A and Raffield, M and Jaffe, ES and Pittaluga, S and Xi, L and Hevaican, T and Iqbal, J and Belhadj, K and Delfau-Larue, MH and Fataccioli, V and Czader, MB and Lossos, IS and Chapman-Fredericks, JR and Richards, KL and Fedoriw, Y and Ondrejka, SL and Hsi, ED and Low, L and Weisenburger, D and Chan, WC and Mehta-Shah, N and Horwitz, S and Bernal-Mizrachi, L and Flowers, CR and Beaven, AW and Parihar, M and Baseggio, L and Parrens, M and Moreau, A and Sujobert, P and Pilichowska, M and Evens, AM and Chadburn, A and Au-Yeung, RKH and Srivastava, G and Choi, WWL and Goodlad, JR and Aurer, Igor and Ba\v{s}i\'{c}-Kinda, Sandra and Gascoyne, RD and Davis, NS and Li, G and Zhang, J and Rajagopalan, D and Reddy, A and Love, C and Levy, S and Zhuang, Y and Datta, J and Dunson, DB and Dave, SS}, year = {2017}, pages = {369-379}, DOI = {10.1158/2159-8290.CD-16-0330}, keywords = {hepatosplenic T-cell lymphoma}, journal = {Cancer Discovery}, doi = {10.1158/2159-8290.CD-16-0330}, volume = {7}, issn = {2159-8274}, title = {The genetic basis of hepatosplenic T-cell lymphoma}, keyword = {hepatosplenic T-cell lymphoma} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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