Naslov
Djelotvornost eravaciklina na enterobakterije otporne na karbapeneme u uvjetima in vitro
(Efficacy of eravacycline on carbapenem resistant Enterobacterales in vitro)

Autori
Jurić, Ivana

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Prirodoslovno-matematički fakultet

Mjesto
Zagreb

Datum
16.12

Godina
2019

Stranica
46

Mentor
Mareković, Ivana ; Ivančić Baće, Ivana

Ključne riječi
eravaciklin ; karbapenem rezistentne Enterobakterales ; beta-laktamaze ; karbapenemaze ; ; in vitro osjetljivost ; disk difuzija ; minimalna inhibitorna koncentracija
(eravacycline ; carbapenem-resistant Enterobacterales (CRE) ; β- lactamases ; carbapenemases ; in vitro susceptibility ; disk diffusion ; minimal inhibitory concentration)

Sažetak
The main obstacle in treatment of infections caused by carbapenem-resistant Enterobacterales (CRE) are limited treatment options. The novel antimicrobial agents other than β-lactams with activity not being dependent on β-lactamase class are especially important. Eravacycline (ERV) is the first fully synthetic fluorocycline indicated for the treatment of complicated intra- abdominal infections in adults. Eighty CRE isolates at the University Hospital Centre Zagreb, Croatia were examined for susceptibility to ERV by disk diffusion method and minimal inhibitory concentration (MIC). Total of 54 (54/80 ; 67.5%) isolates were susceptible to ERV with MIC50 of ≤0.5 μg/mL and MIC90 of 4 μg/mL. Susceptibility of OXA- 48 positive isolates was not significantly higher in comparison with NDM positive (P=0, 539) and VIM positive (P=0, 7805) isolates. ERV is possible alternative to novel β-lactamase inhibitor combinations for treatment of CRE infections with antimicrobial susceptibility testing of CRE isolate to ERV in particular patient as condicio sine qua non before administration.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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