Naslov
Evaluation of cell-mediated immune response by QuantiFERON Monitor Assay in kidney transplant recipients presenting with infective complications
(Evaluation of cell-mediated immune response by QuantiFERON Monitor Assay in kidney transplant recipients presenting with infective complications)

Autori
Margeta, Ivan ; Mareković, Ivana ; Pešut, Ana ; Zelenika, Marina ; Dorotić, Marija ; Mrnjec, Ivana ; Knotek, Mladen

Izvornik
Medicine (0025-7974) 99 (2020), 27; E21010, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
immunosuppression ; infection ; kidney transplantation ; QuantiFERON Monitor

Sažetak
Abstract The net level of immunosuppression in kidney transplant recipients is difficult to assess. QuantiFERON Monitor (QFM) is an in vitro diagnostic test that detects interferon-g (IFN-g) release in peripheral blood. The aim of our study was to compare QFM testing results in stable kidney transplant recipients and kidney transplant recipients with infection, in a single- centre cohort. We enrolled 71 kidney transplant recipients from our transplantation centre. They were divided into 2 groups according to clinical presentation (Stable kidney transplant recipients or Infection). There were no significant differences in interferon-g release between the 2 groups (Stable kidney transplant recipients 140.59± 215.28 IU/ml, Infection group 78.37±197.03 IU/ml, P=.24). A further analysis revealed that kidney transplant recipients presenting with bacterial infection had significantly lower IFN-g release when compared to stable kidney transplant recipients (26.52±42.46 IU/ ml vs 140.59±215.28 IU/ml, P=.04). Kidney transplant recipients presenting with bacterial infection had lower IFN- g release when compared to stable kidney transplant recipients. The QFM test may be useful as a tool to help guide immunosuppression dosing in kidney transplant recipients, but further studies are required to confirm its diagnostic value.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA