Naslov
Lymphatic and small blood vessel density in the tumor and peritumoral tissue in invasive breast carcinoma of no special type

Autori
Kos, Marina ; Leniček, Tanja

Izvornik
Libri oncologici : Croatian journal of oncology (0300-8142) 46 (2018); 5-13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
breast ; invasive ductal carcinoma ; lymphangiogenesis ; angiogenesis

Sažetak
Peritumoral clefts are noticed in carcinomas of many organs, and were thought to be artifacts due to fixation and preparation of slides. Today they are considered to be additional marker of malignancy and the refl ection of epithelial- stromal interaction. The hypothesis was that peritumoral clefts in breast carcinoma reflect changes in stromal composition and characteristics, and are related to lymphangiogenesis in tumor tissue. Materials and methods: One hunderd (59% with axillary lymph nodes metastases) invasive ductal breast carcinomas of no special type were analyzed for the presence and abundance of peritumoral clefts and immunohistochemically for CD34, vimentin, smooth muscle actin (SMA) and D2-40 (podoplanin) in tumor stroma. Results: Peritumoral clefts were found in 92% of invasive carcinomatous tissue and were absent in surrounding healthy tissue and around ducts of in situ component (with 5% do 100%. The threshold of 30% of peritumoral clefts was determined by receiver operating characteristic (ROC) analysis. The density of small lymphatic vessels in the stroma of the tumor, and outside the tumor tissue did not show significant correlation with the threshold value. In patients with axillary metastases, peritumoral lymphovascular invasion (LVI) was found twice and intratumoral LVI five times more often than in patients without axillary metastases. Neither peritumoral nor intratumoral LVI were significantly correlated with the threshold value of 30%. In patients with axillary lymph node metasases, peritumoral lymphovascular invasion (LVI) was found twice as often, and intratumoral LVI 5 times as often than in patients without axillary lymph node metastases. Conclusion: Peritumoral clefts in invasive breast carcinoma reflect stromal changes of fibroblasts and are not associated with lymphangiogenesis, that is probably caused by some other pathogenesis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA