Pregled bibliografske jedinice broj: 119022
P21WAF1/CIP1 is more effective than p53 in growth suppression of mouse renal carcinoma cell line Renca in vitro and in vivo
p21WAF1/CIP1 is more effective than p53 in growth suppression of mouse renal carcinoma cell line Renca in vitro and in vivo // Journal of cancer research and clinical oncology, 129 (2003), 8; 463-471 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 119022 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
P21WAF1/CIP1 is more effective than p53 in growth suppression of mouse renal carcinoma cell line Renca in vitro and in vivo
Autori
Kralj, Marijeta ; Pavelić, Jasminka
Izvornik
Journal of cancer research and clinical oncology (0171-5216) 129
(2003), 8;
463-471
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
p53; p21WAF1/CIP1; gene therapy; apoptosis; Renca cells
Sažetak
Althouhg there are many controversial reports about the effect of p53 and p21 overexpression in different human tumor cells. the p53 gene is shown to be more effective candidate for cancer gene therapy because of its pronounced ability to induce apoptosis. In the present study, we present the effect of p53 and p21 overexpression on mouse renal carcinoma cells in vitro and in vivo. The data suggest that p21 is more potent growth suppressor than p53 of mouse tumor cells Renca. The divergent responses of tumor cells top21 overexpression could be due to various networks that differ between species.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Index Medicus
