Naslov
Novel Aminonaphthalene Photocages for Carboxylic Acids and Alcohols Applied in Organic Synthesis and Biology

Autori
Lovrinčević, Vilma ; Vuk, Dragana ; Škorić, Irena ; Basarić, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Central European Conference on Photochemistry/CECP 2022 / - , 2022, 70-70

Skup
Central European Conference on Photochemistry (CECP 2022)

Mjesto i datum
Bad Hofgastein, Austrija, 13.02.2022. - 17.02.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Aminonaphthalene Photocages ; Protecting Groups ; Photochemical Reactions

Sažetak
Photoremovable protecting groups, also known as photocages, are unique subclass of protect- ing groups which can be removed in photochemical reactions. Photodeprotection reactions often occur under mild conditions without harmful reagents, which is the main reason for their use, not only in synthetic organic chemistry, but also in other fields like medicine and biology [1, 2]. Hydroxymethylaniline derivatives were recently demonstrated as potential photocages for alcohols and carboxylic acids [3]. The efficiency of photodecaging was investigated and it was found out that the meta-derivatives are better photocages for alcohols, whereas the ortho- derivatives are better protective groups for carboxylic acids. Encouraged by these results, dif- ferent substituted aminonaphthalenes as potential photocag- es for alcohols and carboxylic acids were prepared and their photochemistry was investigated in detail by preparative irradiations, fluorescence spectroscopy, and laser flash pho- tolysis. The scope of deprotection has been demonstrated on biologically important carboxylic acids (ibuprofen, keto- profen, etc.) and alcohols (glucose, n-hexanol, etc.).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA