Naslov
Response to Letter to the Editor re ‘The effect of astaxanthin on testicular torsion-detorsion injury in rats - Detailed morphometric evaluation of histological sections’

Autori
Bašković, Marko ; Ježek, Davor

Izvornik
Journal of Pediatric Urology (1477-5131) 18 (2022), 1; 100-101

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, komentar, stručni

Ključne riječi
astaxanthin ; ischemia-reperfusion injury ; testis ; torsion-detorsion

Sažetak
Even though the human body has defence mechanisms in the fight against free oxygen radicals, we are witnessing that at some point, they become insufficient. This upsets the balance between prooxidants and antioxidants favouring prooxidants (a state of oxidative stress). Cell damage is reversible to one point, but cells are subject to irreversible damage under intense and prolonged stress. The biological response of a cell to free oxygen radicals depends on cell type, type of free oxygen radicals, the ability of the cell to remove oxygen free radicals, length of exposure to free oxygen radicals, and concentration of free oxygen radicals. It has generally been shown that low concentrations of free oxygen radicals induce apoptosis, while high ones result in necrosis. To help the body strengthen pre-existing defence mechanisms, researchers around the world are looking for new antioxidants. Astaxanthin has a unique molecular structure that allows it to remain both inside and outside the cell membrane. Structural features such as size, shape, and polarity are critical determinants of astaxanthin's ability to properly blend into its molecular environment for maximum action.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne tehničke znanosti, Kliničke medicinske znanosti

POVEZANOST RADA