Naslov
Immunochemistry assays TRAb vs TSI in patients with thyroid disease

Autori
Vidranski, Valentina ; Krilić, Dražena ; Mlakar Pedišić, Irena ; Jukić, Tomislav ; Punda, Marija ; Bukovec-Megla, Željka ; Franceschi, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract book 9th International Congress of the Croatian Society of Nuclear Medicine / - , 2017, /-/

Skup
9th International Congress of the Croatian Society of Nuclear Medicine

Mjesto i datum
Rovinj, Hrvatska, 04.05.2017. - 07.05.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
thyrotoxicosis, thyrotropin receptor antibodies, antibodies with stimulating activity

Sažetak
Thyrotoxicosis is a condition having multiple etiologies, manifestations, and potential therapies. It refers to a clinical state that results from inappropriately high thyroid hormone action in tissues generally due to inappropriately high tissue thyroid hormone levels. Appropriate treatment of thyrotoxicosis requires an accurate diagnosis which involves among other quantification of thyrotropin-receptor antibodies (TRAb) and/or antibodies with stimulating activity (TSI). The TSH receptor (TSHR) binds autoantibodies, TSI or thyroid blocking immunoglobulins (TBI) that in contrast to TSI inhibit stimulation of thyroid cells leading to hypothyroidism while TSI bind to TSHR and mimic TSH stimulation (hyperthyroidism). TSI includes determination of autoimmune etiology of thyrotoxicosis, conformation of Graves ophalmopathy (GO) or monitoring Graves disease, prediction of remission or relapse and prediction of hyperthyroidism in neonates.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti

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