Naslov
Hydrophobic cavities and diamantanes

Autori
Markuš, Iva ; Usenik, Andrea ; Alešković, Marija ; Šekutor, Marina ; Požar, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIV. susret mladih kemijskih inženjera : knjiga sažetaka = XIV Meeting of Young Chemical Engineers : Book of Abstracts / Žižek, Krunoslav ; Katančić, Zvonimir ; Kovačić, Marin - Zagreb - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2022, 121-121

Skup
XIV. susret mladih kemijskih inženjera (SMLKI 2022)

Mjesto i datum
Zagreb, Hrvatska, 24.02.2022. - 25.02.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
cucurbit[7]uril ; cyclodextrins ; diamondoid alcohols host-guest complexes ; microcalorimetry ; solvophobic effect
(cucurbit[7]uril ; cyclodextrins ; diamondoid alcohols ; host-guest complexes ; microcalorimetry ; solvophobic effect)

Sažetak
Diamantane derivatives are excellent guests for cucurbit[7]uril (CB7), forming complexes with stability constants reaching above petamolar values in water. However, their inclusion within hydrophobic cavities was rarely explored in non- aqueous solutions. We have therefore studied the solvent (water, formamide, ethylene glycol) and temperature effects on the complexation of diamantane alcohols with CB7 and β- and γ- cyclodextrin by means of isothermal microcalorimetry and NMR spectroscopy. Complex stability constants were much higher in water due to less unfavorable ΔrS°. The reactions involving apical alcohols were the most exergonic. A significant temperature dependence of ΔrH° and ΔrS° resulted in an almost perfect enthalpy- entropy compensation for most of the studied host- guest systems. The thermodynamic complexation parameters were in agreement with the classical rationale of the hydrophobic effect at lower temperatures and non-classical explanation at higher ones. The results of 1H NMR titrations were in accord with the thermodynamic studies and have revealed an interesting difference in complex formation kinetics between cucurbit[7]uril and β- cyclodextrin hosts.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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