Naslov
EVALUATION OF WATER MATRIX EFFECT ON DEGRADATION OF PHARMACEUTICALS

Autori
Krpina, Ana ; Samzadeh, Amin ; Cvetnić, Matija ; Furač, Lidija ; Prevarić, Viktorija ; Ukić, Šime ; Bolanča, Tomislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
XIV. susret mladih kemijskih inženjera (SMLKI 2022)

Mjesto i datum
Zagreb, Hrvatska, 24.02.2022. - 25.02.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Pantoprazole ; pharmaceuticals ; advanced oxidation processes ; water

Sažetak
In this study one widely used recalcitrant pharmaceutical that has potential to be on the watch list was chosen for its degradation study. There was an evaluatation of the influence of several water matrix factors on pharmaceutical degradation with advanced oxidation processes (AOPs). To the best of our knowledge so far, there has been no research comparing UV-C, ultrasound (US) and microwave (MW) based processes under different operational parameters (oxidant dosage, pH, humic acid, nitrite ion, nitrate ion, chloride ion, phosphate ion and sulfate ion). Each of these factors depending on the degradation process, had synergistic or inhibitory effect on degradation rate of studied pharmaceutical. Design of the experiment that was used was Taguchi method. It shows significant results and indicates the effect of studied factors on degradation processes that, in most cases, were in agreement with previous literature findings, also it reduces the number of required experiments, time, and costs. Water matrix constituents had a significant impact on the degradation efficiency.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti

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