Naslov
OSTEORHEUMATOLOGY: CURRENT KNOWLEDGE AND PERSPECTIVE

Autori
Radic, Mislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2016): Non-sponsored Symposia Abstracts / - : Springer Science+Business Media, 2016, 555-577

Skup
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2016)

Mjesto i datum
Málaga, Španjolska, 14.04.2016. - 17.04.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
osteorheumatology, bone metabolism, inflammation

Sažetak
Objective: The growing awareness about the relevant interactions between the bone, the cartilage and the immune system in a number of rheumatic diseases encouraged the development of a new discipline in the field of rheumatology, clinical immunology and endocrinology called osteorheumatology. The basic idea underlying osteorheumatology is the importance of the crosstalk between inflammation, cartilage and subchondral bone in rheumatic diseases such as rheumatoid arthritis (RA), osteoarthritis (OA) and spondyloarthropathies (SpA). The bone damage as an early manifestation of arthritides, the systemic skeletal involvement in RA, the crucial role played by subchondral bone in the pathogenesis and progression of OA, the pathophysiology of glucocorticoids damage on the bone tissue, and the potential beneficial effects of newly approved agents such as bisphosphonates, denosumab and biologics have become the object of experimental and clinical studies over the past 20 years. Methods: A systematic literature search was carried out in Medline ; Embase ; Cochrane Library and ACR/EULAR meeting abstracts. Results: In RA inflammatory cytokines like TNFα, IL-1 or IL-6 foster bone resorption and inhibit bone formation, resulting in an imbalance of bone homeostasis and thereby precipitating bone loss. Inflammatory cytokines particularly enhance bone loss by activation of osteoclast differentiation factors such as macrophage colony- stimulating factor (M-CSF) and RANK ligand and by molecules which interfere with bone formation such as dickkopf Wnt signaling pathway inhibitor 1 (Dkk1) and sclerostin. In OA the local accumulation of insulin growth factor-1 (IGF-1), which is a potent stimulator of bone formation, contributes to the subchondral bone sclerosis in OA. Furthermore, IL-6, prostaglandin-E2 and receptor activator of nuclear factor κ-B ligand (RANKL) may be responsible for increased number of osteoclasts in OA and bone resorption. OA experimental models have shown that cytokines regulate bone formation and interaction of osteoclasts with the bone substrate which also provides a potent signal to induce the osteoclast differentiation. Several animal models have highlighted the role of BMP and Wnt signaling in the process of ankylosis in SpA patients. Human data further supported these animal observations. Conclusion: Osteorheumatology is a new scientific discipline which is rapidly evolving, studying the mutual effects of the skeleton and immune systems at the cellular and molecular levels, both in physiologic as in pathologic conditions

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA