Naslov
Review of the bladder cancer molecular classification proposed: a new era – new taxonomy

Autori
Šoipi, Šopi ; Vučić, Majda ; Spajić, Borislav ; Krušlin, Božo ; Tomić, Miroslav ; Ulamec, Monika

Izvornik
Acta clinica Croatica (0353-9466) 60 (2021), 3; 519-524

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
bladder cancer ; molecular classification

Sažetak
The management of bladder cancer patients largely depends on pathologic staging and grading, and current morphological classification does not always show the individual patient’s risk. Despite modern surgical techniques, pre- and postoperative therapies, clinical outcomes of these patients have not changed over decades. Today, there are new biomarkers for bladder cancer showing changes in tumor biology and progression, as a result of changes in the pathways affecting cell signaling, proliferation, apoptosis, epigenetic changes, angiogenesis, and modulation of host immune response. Assessment of multiple biomarkers associated with those pathways offers new understanding of tumor behavior while identifying important panels of predicting patient management and outcomes. In this review, the most important molecules and basics of the novel molecular classification of bladder cancer are presented.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA