Naslov
Sjögren’s syndrome - immunological mechanisms, clinical presentation and management

Autori
Julia Anastasia Raith

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Medicinski fakultet

Mjesto
Zagreb, Hrvatska

Datum
16.07

Godina
2021

Stranica
32

Mentor
Markeljević, Jasenka

Ključne riječi
Sjogren's syndrome ; sicca symptoms ; autoimmune diseases

Sažetak
Sjögren Syndrome (SS) is a chronic systemic autoimmune disease of unknown etiology, primarily affecting the exocrine glands. Clinically, this manifests as decreased secretion of lacrimal glands and salivary glands with a feeling of dry eyes (xerophthalmia) and a dry oral mucosa (xerostomia), as well as dryness of the mucous membranes of the respiratory, gastrointestinal, and urogenital systems. In addition to the glandular manifestations, extra glandular manifestations can also occur. These involve the musculoskeletal system, the interstitium of the lungs, internal organs, and the peripheral and central nervous systems. Primarily affecting women in their 5th and 6th decades of life, Sjögren’s syndrome is the most common autoimmune disease after rheumatoid arthritis (RA). The Immunopathogenesis of SS includes a dysregulation in the interaction of endogenous and exogenous factors at systemic and local levels in genetically predisposed individuals. Sjögren’s syndrome may manifest as primary Sjögrens syndrome (pSS) or secondary if associated with other autoimmune diseases. The diagnostic procedure is based on the diagnostic criteria established by the American-European Consensus Group in 2002, which have been revised several times since then and include a variety of diagnostic tests, including the Schirmer test, serology, biopsy, and imaging. In the past, the treatment of Sjögren’s syndrome has mainly focused on relieving the symptoms and suppressing the immune system, more recently the subject of research has been immunotherapy, biological therapy, and stem cell therapy. As an alternative therapy, Chinese medicine has shown a positive effect on patients with Sjögren Syndrome

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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