Naslov
THE USE OF SINGLE PILL COMBINATION IN TREATMENT OF HYPERTENSION AMONG DALMATIAN PATIENTS IN NEPHROLOGY OUTPATIENT CLINIC

Autori
Radic, Josipa ; Milin, S. ; Novak, I. ; Culjak, Z.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Skup
29th European Meeting on Hypertension and Cardiovascular Protection (ESH 2019)

Mjesto i datum
Milano, Italija, 21.06.2019. - 24.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hypertension, nephrology

Sažetak
Objective: Evidence suggests that most hypertensive patients require two drugs or more to achieve optimal and sustained blood pressure control. It is well known that fixed-dose combinations, also known as single pill combinations, which incorporate two antihypertensive drugs or more into one pill, can improve control rates without increasing the risk of adverse events. The aim of this study was to determinate frequency of using single pill combinations among hypertensive patients in nephrology outpatient clinic and difference in blood pressure and other biochemical parameters among two groups of patients. Design and method: The study included 201 subjects, 112 (55.7%) men aged 68.5 (59.3 – 75.8) years and 89 (44.3%) women aged 68 (59.5 - 73) years. Data for age, gender, type and number of antihypertensive drugs were recorded. Serum values of urea, creatinine, haemoglobin and potassium have been measured and glomerular filtration rate (GFR) was calculated for each patient. The device Agedio B900 was used to measure parameters of arterial pressure. Peripheral and central systolic and diastolic arterial pressure were measured. Also, pulse pressure and mean arterial pressure were calculated for peripheral and central arterial pressure. Results: 67 (33.3%) patient were taking single pill combination. Those patients with single pill combination had statistically lower urea (8.1 (6–2– 10.6) vs. 10 (7–15.93), p = 0.01), creatinine (101 (76 - 139) vs. 134 (89.75 – 198.75), p = <0.001) and statistically higher haemoglobin level (141 (131 - 152) vs. 132 (119 - 146), p = 0.04) and GFR (61.5 (42.6 - 82) vs. 39.45 (25.4 – 69.65), p = <0.001) than those patient without single pill combination. Statistically significant difference in potassium level and measured blood pressure parameters was not found among these two group of patients. Conclusions: Low proportion of hypertensive patients were taking single pill combination. Possible explanation for this finding could be statistically higher creatinine level and low GFR in those patients without single pill combination. Chronic kidney disease among hypertensive patients in nephrology outpatient clinic could be possible reason for not prescribing single pill combination, especially those single pill combination with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA