Pregled bibliografske jedinice broj: 1181852
Development of structurally defined saponin-based vaccine adjuvants
Development of structurally defined saponin-based vaccine adjuvants // 27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2021. str. 26-26 (pozvano predavanje, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 1181852 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Development of structurally defined saponin-based
vaccine adjuvants
Autori
Škalamera, Đani
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts
/ Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 26-26
Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI) ; 5. simpozij Vladimir Prelog
Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Domaća recenzija
Ključne riječi
Quillaja saponaria, immunoadjuvants, oligosaccharide synthesis
Sažetak
Adjuvants are substances that enhance the immunogenicity of a vaccine in order to achieve strong and durable immune responses to specific antigens. Immunoadjuvants isolated from the Quillaja saponaria Molina tree bark are very promising candidates in the development of synthetic structurally defined vaccine adjuvants. The lead compound from this series, QS-21, is one of the most potent adjuvants known to date. After being studied in over 100 clinical trials, it is finally approved for human use (herpes zoster vaccine Shingrix®, GSK). Many clinical trials of QS-21 in vaccines against infectious diseases and cancer are currently on the way. However, Quillaja saponins (QS) have inherent drawbacks which restrain their wider use, such as: chemical instability, limited supply, laborious purification process and dose-limiting toxicity. Therefore, there is a need for the development of structurally defined, homogeneous and simplified QS saponin-based adjuvants with improved chemical stability and synthetic accessibility. Chemical synthesis is currently the only viable way to access structurally defined QS analogs in a sufficient amount for adjuvant screenings and potential application in clinics. The lecture will focus on the recent progress in the design, synthesis, and immunological evaluations of new QS analogs based on the structures of natural QS-7 and QS-17/18 Quillaja saponins.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
MZO Ustanova-Hrvatska akademija znanosti i umjetnosti-818307 - Sinteza i ispitivanje imunoadjuvantske aktivnosti konjugata desmuramil-dipeptida i saponina kvilaje (Quillaja saponaria) (MurQuil) (Škalamera, Đani, MZO Ustanova - JAVNI NATJEČAJ ZAKLADE HAZU ZA POTPOMAGANJE ZAKLADNIH NAMJENA U 2020. GODINI) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
Profili:
Đani Škalamera
(autor)
