Naslov
THE LEVEL OF MALNUTRITION RISK CORRELATES WITH SARCOPENIA, DISEASE ACTIVITY AND SEVERITY AND ORAL AND GLOBAL HEALTH-RELATED QUALITY OF LIFE IN SYSTEMIC SCLEROSIS PATIENTS

Autori
Radic, M ; Boric, K ; Bozic, I ; Kalitema, DM

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2018)

Mjesto i datum
Kraków, Poljska, 19.04.2018. - 22.04.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MALNUTRITION, SARCOPENIA, SYSTEMIC SCLEROSIS

Sažetak
Objective: Systemic sclerosis (SSc) is a rare connective tissue disease, clinically characterized by disorders in vascular, immunological and fibrotic pathways. Nutritional status is used as a marker for disease activity and severity, predicting mortality in Ssc patients. Ssc is an autoimmune disease which may lead to malnutrition. The aim of this study was to compare SSc patients with medium and high risk of malnutrition and to determine the possible association of malnutrition risk with oral healthrelated quality of life (HRQoL), global HRQoL, gastrointestinal symptoms, sarcopenia and disease activity and severity. Methods: Subjects were recruited from Croatian SSc Center of excellence cohort. Malnutrition was defined according to recently published ESPEN criteria and malnutrition risk was measured using the Malnutrition Universal Screening Tool (MUST). The OHIP 49 was used to measure the dental outcomes in terms of its influence on the oral HRQoL. Global HRQoL was measured using the Medical Outcomes Trust SF-36 Health Survey. To explore gastrointestinal symptoms, UCLA questionnaire was administered. Sarcopenia was evaluated using skeletal muscle mass index. Results: Fifty-one consecutive SSc patients with malnutrition risk and active disease were enrolled in this study-26 with high malnutrition risk and 25 with medium risk. The prevalence of sarcopenia was higher in SSc patients with high MUST (p<0.05, chi square for linear trend). Severity of oral and global HRQoL was different between Ssc patients with high and medium MUST (p=0.002 and p=0.03, respectively ; chi-square for linear trend). Unexpectedly, Ssc patients with high MUST did not have worse gastrointestinal symptoms according to UCLA SCTC GIT 2.0 questionnaire (p=0.09). Severity score according to Medsger and activity score according to Valentini were higher in Ssc patients with high MUST than in SSc patients with medium (p<0.05, p<0.05, respectively ; chi-square for linear trend). Conclusion: Our data suggest that level of malnutrition risk measured by MUST correlates with prevalence of sarcopenia in Ssc. Oral and global HRQoL are associated with level of malnutrition risk in Ssc patients. Gastrointestinal involvement (symptoms), however, is not related with level of malnutrition risk. Nutritional status can provide some prognostic information in Ssc.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA