Naslov
ASSOCIATION OF BODY COMPOSITION WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS

Autori
Radic, M

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2020)

Mjesto i datum
Online, 20.08.2020. - 22.08.2020

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BODY COMPOSITION, RHEUMATOID ARTHRITIS

Sažetak
Rheumatoid arthritis (RA) is a chronic form of inflammatory arthritis characterized by multiple joint involvement and significant disability. The term “body composition” refers to the quantification of the different structural components of the human body, which can be estimated at the atomic, molecular, cellular, organ-tissue and whole body levels. Several studies showed that RA is associated with considerable changes in body composition, lipid profile, adipokines and insulin sensitivity. Overweight and obesity are increasing the risk of metabolic, neoplastic and cardiovascular diseases, but can be considered states of inflammatory activation, since the hypertrophic adipocytes of individuals with body compositions of these types are activated and release a number of soluble mediators known as adipocytokines or adipokines. The most important adipokines in terms of their proinflammatory activity are leptin, visfatin, interleukin 1 and tumor necrosis factor α. The latter 2 cytokines are relevant in the pathogenesis RA, as they are crucial for the onset and persistence of the destructive synovitis that characterize this disease. Several studies have evaluated the association between changes in body composition in terms of measurements of overweight or obesity and the level of disease activity in RA patients are contradictory. The reasons for this controversy very probably lie in the heterogeneity or weakness of the evaluation tools used both for body composition and the level of disease activity associated with RA, as well as weaknesses in the design and quality of the sample selection. The modulation of RA clinical status by body fat mass is suggested because a significant association was found between body mass index (BMI) and inflammatory activity in those reports with a trend toward higher statistical power. The body composition is already altered in patients with early RA with more fat and less lean mass, with or without an increase in the BMI. Various studies describe the association between high BMI categories and poorer clinical outcomes, a lower chance for remission, and a higher probability of comorbidity but less radiographic joint damage. Body compositions such as body fat mass and skeletal muscle mass are significantly associated with pain and disability in RA patients. The relationship between body composition and clinical activity in RA requires be approached with further studies with higher methodological quality.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA