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Pregled bibliografske jedinice broj: 1181694

Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma

Petersson, Fredrik; Sperga, Maris; Bulimbasic, Stela; Martinek, Petr; Svajdler, Marian; Kuroda, Naoto; Hora, Milan; Simpson, Roderick; Tichy, Tomáš; Peckova, Kvetoslava et al.
Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma // Virchows Archiv, 465 (2014), 2; 215-224 doi:10.1007/s00428-014-1600-z (međunarodna recenzija, pregledni rad, znanstveni)

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Naslov
Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma

Autori
Petersson, Fredrik ; Sperga, Maris ; Bulimbasic, Stela ; Martinek, Petr ; Svajdler, Marian ; Kuroda, Naoto ; Hora, Milan ; Simpson, Roderick ; Tichy, Tomáš ; Peckova, Kvetoslava ; Branzovsky, Jindrich ; Pivovarcikova, Kristyna ; Rotterova, Pavla ; Kokoskova, Bohuslava ; Bauleth, Kevin ; Martincok, Dusan ; Nagy, Vincent ; Michal, Michal ; Hes, Ondrej

Izvornik
Virchows Archiv (0945-6317) 465 (2014), 2; 215-224

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
renal cell carcinoma, foamy, hibernoma-like

Sažetak
We report nine patients (seven males and two females, median age 64 years (range 51-79 years)) with a renal cell carcinoma, each of which contained a significant component of neoplastic epithelial cells with a striking microvacuolated (hibernoma-like) cytoplasmic appearance. Tumor sizes ranged from 1.5 to 8.0 cm (mean 4.2 cm, median 4.3 cm). The basic architecture of the tumors was solid-alveolar in two cases (classified as renal cell carcinoma-not otherwise specified (NOS)) and papillary in seven cases (classified as papillary renal cell carcinoma NOS). The nuclear grade according to the Fuhrman grading system was three in all cases. By immunohistochemistry, the cells with microvacuolated cytopasm and significantly expressed adipophilin and anti- mitochondrial antigen in a similar cytoplasmic pattern. On ultrastructural examination, the cytoplasm of the neoplastic epithelial cells was packed with distended mitochondria, most of which displayed lamellated cristae. Numerous microvesicles were dispersed between the mitochondria. No mutations in the succinate dehydrogenase B gene were identified. Based on our findings, we propose that the mechanism behind this phenomenon is an abnormal intracellular processing of lipids. No aggressive behavior was observed in six out of nine patients with available follow-up information.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Profili:

Avatar Url STELA BULIMBAŠIĆ (autor)

Poveznice na cjeloviti tekst rada:

doi link.springer.com

Citiraj ovu publikaciju:

Petersson, Fredrik; Sperga, Maris; Bulimbasic, Stela; Martinek, Petr; Svajdler, Marian; Kuroda, Naoto; Hora, Milan; Simpson, Roderick; Tichy, Tomáš; Peckova, Kvetoslava et al.
Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma // Virchows Archiv, 465 (2014), 2; 215-224 doi:10.1007/s00428-014-1600-z (međunarodna recenzija, pregledni rad, znanstveni)
Petersson, F., Sperga, M., Bulimbasic, S., Martinek, P., Svajdler, M., Kuroda, N., Hora, M., Simpson, R., Tichy, T. & Peckova, K. (2014) Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma. Virchows Archiv, 465 (2), 215-224 doi:10.1007/s00428-014-1600-z.
@article{article, author = {Petersson, Fredrik and Sperga, Maris and Bulimbasic, Stela and Martinek, Petr and Svajdler, Marian and Kuroda, Naoto and Hora, Milan and Simpson, Roderick and Tichy, Tom\'{a}\v{s} and Peckova, Kvetoslava and Branzovsky, Jindrich and Pivovarcikova, Kristyna and Rotterova, Pavla and Kokoskova, Bohuslava and Bauleth, Kevin and Martincok, Dusan and Nagy, Vincent and Michal, Michal and Hes, Ondrej}, year = {2014}, pages = {215-224}, DOI = {10.1007/s00428-014-1600-z}, keywords = {renal cell carcinoma, foamy, hibernoma-like}, journal = {Virchows Archiv}, doi = {10.1007/s00428-014-1600-z}, volume = {465}, number = {2}, issn = {0945-6317}, title = {Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma}, keyword = {renal cell carcinoma, foamy, hibernoma-like} }
@article{article, author = {Petersson, Fredrik and Sperga, Maris and Bulimbasic, Stela and Martinek, Petr and Svajdler, Marian and Kuroda, Naoto and Hora, Milan and Simpson, Roderick and Tichy, Tom\'{a}\v{s} and Peckova, Kvetoslava and Branzovsky, Jindrich and Pivovarcikova, Kristyna and Rotterova, Pavla and Kokoskova, Bohuslava and Bauleth, Kevin and Martincok, Dusan and Nagy, Vincent and Michal, Michal and Hes, Ondrej}, year = {2014}, pages = {215-224}, DOI = {10.1007/s00428-014-1600-z}, keywords = {renal cell carcinoma, foamy, hibernoma-like}, journal = {Virchows Archiv}, doi = {10.1007/s00428-014-1600-z}, volume = {465}, number = {2}, issn = {0945-6317}, title = {Foamy cell (hibernoma-like) change is a rare histopathological feature in renal cell carcinoma}, keyword = {renal cell carcinoma, foamy, hibernoma-like} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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