Naslov
Influence of the local inflammation of the peritoneal membrane on the residual renal function in patients treated with peritoneal dialysis
(Influence of the local inflammation of the peritoneal membrane on the residual renal function in patients treated with peritoneal dialysis)

Autori
Jelicic, I. ; Ljutic, D. ; Pehar, G. ; Filipovic, T. ; Sain, M. ; Skaro, D. Boric ; Wilhelm, V. ; Kovacic, V. ; Radic, J.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Nephrology

Mjesto i datum
Pariz, Francuska, 01.01.2008. - 03.01.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
inflammation, peritoneal membrane

Sažetak
The aim of this study was to investigate the connection between local inflammation of the peritoneal membrane and diuresis, as well as the residual renal function (RRF) in patients treated with continuous ambulatory peritoneal dialysis (CAPD). Twenty patients treated with CAPD participated in this cross-sectional study. To determine the influence of local inflammation of the peritoneal membrane, effluent interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R) levels were measured. The level of IL-6, in the group as a whole, was significantly higher in effluent (7.87 pg/mL) than in serum (1.29 pg/mL). There was a significant correlation between effluent and serum IL-6 (r = 0.608 ; P = 0.002). There was also a significant relationship between effluent and serum IL-6 and duration of CAPD treatment, respectively (r = 0.577 ; P = 0.004 ; r = 0.528 ; P = 0.008). Further, there was a significant negative correlation between effluent IL-6 and daily diuresis (r = -0.533 ; P = 0.008), but there was no significant correlation between effluent IL-6 and RRF (r = -0.339, P = 0.072). On the other hand, the concentrations of effluent IL- 6 were significantly higher in patients with RRF <2 mL/min than in those with RRF ≥2 mL/min (P = 0.039). In conclusion, local inflammation has a significant impact on the amount of diuresis and probably on RRF in patients on CAPD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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