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Pregled bibliografske jedinice broj: 1181244

Clear cell renal cell carcinoma with Paneth-like cells: Clinicopathologic, morphologic, immunohistochemical, ultrastructural, and molecular analysis of 13 cases

Kojima, Fumiyoshi; Bulimbasic, Stela; Alaghehbandan, Reza; Martinek, Petr; Vanecek, Tomas; Michalova, Kvetoslava; Pivovarcikova, Kristyna; Michal, Michal; Hora, Milan; Murata, Shin-ichi et al.
Clear cell renal cell carcinoma with Paneth-like cells: Clinicopathologic, morphologic, immunohistochemical, ultrastructural, and molecular analysis of 13 cases // Annals of Diagnostic Pathology, 41 (2019), 96-101 doi:10.1016/j.anndiagpath.2019.05.012 (međunarodna recenzija, pregledni rad, znanstveni)

CROSBI ID: 1181244 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Clear cell renal cell carcinoma with Paneth-like cells: Clinicopathologic, morphologic, immunohistochemical, ultrastructural, and molecular analysis of 13 cases

Autori
Kojima, Fumiyoshi ; Bulimbasic, Stela ; Alaghehbandan, Reza ; Martinek, Petr ; Vanecek, Tomas ; Michalova, Kvetoslava ; Pivovarcikova, Kristyna ; Michal, Michal ; Hora, Milan ; Murata, Shin-ichi ; Sugawara, Emiko ; Rogala, Joanna ; Limani, Rinë ; Hes, Ondrej

Izvornik
Annals of Diagnostic Pathology (1092-9134) 41 (2019); 96-101

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Clear cell renal cell carcinoma ; Immunohistochemistry ; Kidney ; Next generation sequencing ; Paneth-like cells.

Sažetak
Clear cell renal cell carcinoma (CRCC) is well known for its intratumoral heterogeneity. Paneth- like cells (PLC) have been reported in variable organs (i.e., hepatobiliary, genitourinary, and female genital tract). In genitourinary system, it is possible to find PLCs in epididymis, urinary bladder and prostate. The objective of this study was to assess PLC in CRCCs 13 CRCCs with prominent PLC (CRCCPLC) were selected out of 1378 CRCCs in our registry. The tumors were analyzed using morphologic, immunohistochemical, ultrastructural, and molecular genetic methods. CRCCPLCs were mostly of low histologic grade (12/13). Immunohistochemical profile was compatible with classic CRCC. PLC constituted 10 to-70% of the tumor volume (mean 17.7%, median 10%). PLCs did not express neuroendocrine markers (chromogranin, synaptophysin, CD56, INSM-1). Ultrastructurally, PLCs were filled by membrane bounded vesicles of various sizes and were compatible with secretory type of cells. VHL mutation was found in 9/9 cases, and LOH3p was found in 6/8 analyzable cases. Conclusions: PLC morphology can variably be present in "classic" CRCC, even in a substantial proportion. Ultrastructurally, PLCs have all attributes of secretory cells. Preliminary follow up data showed that these tumors may not be associated with aggressive clinical behavior.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Profili:

Avatar Url STELA BULIMBAŠIĆ (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Kojima, Fumiyoshi; Bulimbasic, Stela; Alaghehbandan, Reza; Martinek, Petr; Vanecek, Tomas; Michalova, Kvetoslava; Pivovarcikova, Kristyna; Michal, Michal; Hora, Milan; Murata, Shin-ichi et al.
Clear cell renal cell carcinoma with Paneth-like cells: Clinicopathologic, morphologic, immunohistochemical, ultrastructural, and molecular analysis of 13 cases // Annals of Diagnostic Pathology, 41 (2019), 96-101 doi:10.1016/j.anndiagpath.2019.05.012 (međunarodna recenzija, pregledni rad, znanstveni)
Kojima, F., Bulimbasic, S., Alaghehbandan, R., Martinek, P., Vanecek, T., Michalova, K., Pivovarcikova, K., Michal, M., Hora, M. & Murata, S. (2019) Clear cell renal cell carcinoma with Paneth-like cells: Clinicopathologic, morphologic, immunohistochemical, ultrastructural, and molecular analysis of 13 cases. Annals of Diagnostic Pathology, 41, 96-101 doi:10.1016/j.anndiagpath.2019.05.012.
@article{article, author = {Kojima, Fumiyoshi and Bulimbasic, Stela and Alaghehbandan, Reza and Martinek, Petr and Vanecek, Tomas and Michalova, Kvetoslava and Pivovarcikova, Kristyna and Michal, Michal and Hora, Milan and Murata, Shin-ichi and Sugawara, Emiko and Rogala, Joanna and Limani, Rin\"{e} and Hes, Ondrej}, year = {2019}, pages = {96-101}, DOI = {10.1016/j.anndiagpath.2019.05.012}, keywords = {Clear cell renal cell carcinoma, Immunohistochemistry, Kidney, Next generation sequencing, Paneth-like cells.}, journal = {Annals of Diagnostic Pathology}, doi = {10.1016/j.anndiagpath.2019.05.012}, volume = {41}, issn = {1092-9134}, title = {Clear cell renal cell carcinoma with Paneth-like cells: Clinicopathologic, morphologic, immunohistochemical, ultrastructural, and molecular analysis of 13 cases}, keyword = {Clear cell renal cell carcinoma, Immunohistochemistry, Kidney, Next generation sequencing, Paneth-like cells.} }
@article{article, author = {Kojima, Fumiyoshi and Bulimbasic, Stela and Alaghehbandan, Reza and Martinek, Petr and Vanecek, Tomas and Michalova, Kvetoslava and Pivovarcikova, Kristyna and Michal, Michal and Hora, Milan and Murata, Shin-ichi and Sugawara, Emiko and Rogala, Joanna and Limani, Rin\"{e} and Hes, Ondrej}, year = {2019}, pages = {96-101}, DOI = {10.1016/j.anndiagpath.2019.05.012}, keywords = {Clear cell renal cell carcinoma, Immunohistochemistry, Kidney, Next generation sequencing, Paneth-like cells.}, journal = {Annals of Diagnostic Pathology}, doi = {10.1016/j.anndiagpath.2019.05.012}, volume = {41}, issn = {1092-9134}, title = {Clear cell renal cell carcinoma with Paneth-like cells: Clinicopathologic, morphologic, immunohistochemical, ultrastructural, and molecular analysis of 13 cases}, keyword = {Clear cell renal cell carcinoma, Immunohistochemistry, Kidney, Next generation sequencing, Paneth-like cells.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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