Naslov
RESISTANT ARTERIAL HYPERTENSION AND ARTERIAL STIFFNESS IN RENAL TRANSPLANTATION RECIPIENTS

Autori
Raos, H. ; Vuckovic, M. ; Bucan Nenadic, D. ; Radic, Josipa

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Skup
29th European Meeting on Hypertension and Cardiovascular Protection (ESH 2019)

Mjesto i datum
Milano, Italija, 21.06.2019. - 24.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
arterial stiffness, kidney transplant

Sažetak
Objective: In renal transplantation recipients (RTRs), several factors could accelerate the stiffness process, such as the use of calcineurin inhibitors (CNIs), the presence of chronic kidney disease and other classical cardiovascular factors (arterial hypertension), which would explain, at least in part, the high cardiovascular mortality and morbidity. The aim of this study was to evaluate difference in parameters of arterial stiffness, blood pressure and body composition among hypertensive RTCs with special focus on resistant arterial hypertension (RAH) Image Design and method: 89 RTRs, 48 (53.93%) men and 41 (46.07%) women, aged 59.31 years were included. For each RTRs patient data about number and type of antihypertensive drugs, age, gender, body weight and height were collected. Also, serum urea and creatinine were measured and body mass index (BMI) and glomerular filtration (GF) was calculated. The Agedio B900 device was used to measure arterial pressure (peripheral and central systolic as well as peripheral and central diastolic arterial pressure) and parameters of arterial stiffness (pulse wave velocity (PWV) and augmentation Index (AIx). Furthernore, Tanita MC780 Multi Frequency segmental body composition analyser was used to measure content of body fat, muscle mass and visceral fat each study subject. Results: 78 RTRs have AH (91.76%) and 53 (67.94%) of them have RAH. Those RTRs with RAH have statistically higher value of serum urea (p = 0.003) and creatinine (p = 0.007) and lower GF (p = 0.007). Also, those patients have higher BMI (p = 0.035) and muscle mass (p = 0.028), but significant differences in fat tissue parameters were not found. Therefore, RTRs with RAH have significantly higher value PWV (p = 0.046) and Alx (p = 0.048) Statistically significant differences in age and blood pressure parameters were not found between those two groups of RTCs as shown in Table 1. Conclusions: Prevalence of RAH is high in RTRs and those patient with RAH have higher arterial stiffness and lower kidney functions although they were not significantly older than those hypertensive RTRs without RAH. RTRs with RAH could be especially vulnerable population of patients and experience higher mortality and morbidity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA