Naslov
Severe bleeding caused by piperacillin/tazobactam- induced platelet dysfunction

Autori
Skoric, Bosko ; Agic, Antonio ; Pasalic, Marijan ; Samardzic, Jure ; Milicic, Davor

Izvornik
International journal of clinical pharmacology and therapeutics (0946-1965) 58 (2020), 08; 454-456

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
piperacillin/tazobactam, adverse effect, bleeding complication, platelet dysfunction

Sažetak
Objective: Piperacillin/tazobactam (TZP ) is commonly used against multi-resistant nosocomial Pseudomonas infections. While TZP-induced thrombocytopenia is a well-known and easily diagnosed complication, we herein present an unusual case of spontaneous TZP- induced bleeding caused by platelet dysfunction. Case summary: A 73-year-old-man experienced severe pulmonary hemorrhage and bloody diarrhea during the treatment with TZP for Pseudomonas aeruginosa ventilator-associated pneumonia. While both platelet count and coagulation tests were normal, platelet functional test revealed severely impaired ADP- dependent platelet aggregation. Conclusion: Platelet dysfunction is a little-known mechanism of TZP- induced bleeding. This is the second reported case of TZP-related bleeding that has been attributed to platelet dysfunction, and the first case report that has not been associated with surgery. While thrombocytopenia is easily recognized, this form of TZP-induced bleeding can be detected only by platelet functional tests.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA