Naslov
Post COVID-19 manifestations on esophageal motility – reality or speculation
(Post COVID-19 manifestations on esophageal motility – reality or speculation)

Autori
Babić, Žarko ; Škunca, Jelena ; Medić, Barbara ; Andabak, Maja ; Banić, Marko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta clinica Croatica. Supplement, 60 (2021), 2 / Ljubičić, Neven ; Virović Jukić, Lucija - Zagreb : Hrvatsko gastroenterološko društvo, 2021, 77-77

Skup
9. kongres Hrvatskog gastroenterološkog društva = 9th congress of the Croatian society of gastroenterology

Mjesto i datum
Zagreb, Hrvatska, 28.10.2021. - 30.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
post COVID-19 ; esophageal motility

Sažetak
Introduction and Aim: The acute Covid-19 infection can cause changes on many organs, but the changes in post infection period is not uncommon (1, 2). The aim of this study is to detect the relationship of infection on changes of esophageal motility (manometry parameters) in post COVID-19 infection period. Methods: We repeatedly evaluated the group 21 patient after clinical recovery from COVID-19 disease, who were diagnosed with ineffective esophageal motility, previous to infection with SARS-CoV-2 virus. All the patients enrolled were submitted to reevaluation because of chest discomfort, swallowing problems and dysphagia. The potential coexistence of gastroesophageal reflux disease was excluded clinically and on 24-hours impedance monitoring. Measurements were perfiormed on MMS HRM 360 ° system using 36 chanel watter perfused catheters according to Chichago 3 protocol (3). Results: Using high-resolution esophageal manometry, and comparing the results to previous functional evaluation before COVID-19 disease, we detected the significant lowering of distal contractile integral (321, 2 ± 111.5 mmHg.s.cm vs. 212.85 ± 115.08 mmHg.s.cm) and prolongation of distal latency (5, 81 ± 0.91 s vs. 9.75 ± 4.66 s), according to Chicago 3.0 Classification, in all the patients (P<0.05). In the peristaltic break 2.78 ± 0.59 cm vs. 5.21 ± 6.16 cm we detected borderline significance (P<0, 48). In the contractile front velocity (cm/s), the upper esophageal sphincter pressure (mmHg) and the lower esophageal sphincter pressure (mmHg) we did not detect significant diference (P>0, 05). Conclusion: As a part of ongoing study, the preliminary results of first 21 patients included indicate the possible influence of SARS-CoV-2 infection on esophageal motility. The further research is needed in order to confirm the preliminary results and elucidate the possible mechanisms. This study was registered in ClinicalTrials.gov, under Identifier: NCT04988438 Reference: 1. Gupta A, Madhaven MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, et al. Extrapulmonary manifestations of COVID-19. Nature Medicine 2020 ; 26:1017-1032. 2. Leal T, Costa E, Arroja B, Goncalves R, Alves J. Gastrointestinal manifestations of COVID- 19: results from a European centre. Eur J Gastroenterol and hepatol 2021 ; 33(5):691691. 3. Herbela FA, Armijo PR, Pastti MG. A pictorial presentation of 3.0 Chichago Classification for esophageal motility disorder. Einstein 2016 ; 14(3):439-42. e-mail: zarko.babic@zg.t-com.hr

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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