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Pregled bibliografske jedinice broj: 1180112

Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia

Maysinger, Dusica; Sanader Maršić, Željka; Gran, Evan Rizzel; Shobo, Adeola; Macairan, Jun-Ray; Zhang, Issan; Perić Bakulić, Martina; Antoine, Rodolphe; Multhaup, Gerhard; Bonačić-Kouteckỳ, Vlasta
Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia // ACS Chemical Neuroscience, 13 (2022), 4; 464-476 doi:10.1021/acschemneuro.1c00621 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1180112 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia

Autori
Maysinger, Dusica ; Sanader Maršić, Željka ; Gran, Evan Rizzel ; Shobo, Adeola ; Macairan, Jun-Ray ; Zhang, Issan ; Perić Bakulić, Martina ; Antoine, Rodolphe ; Multhaup, Gerhard ; Bonačić-Kouteckỳ, Vlasta

Izvornik
ACS Chemical Neuroscience (1948-7193) 13 (2022), 4; 464-476

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gold nanocluster ; microglia ; HMGB1 ; cell death ; lipid peroxidation ; glutathione ; oxidative stress ; molecular modeling ; QM/MM simulations

Sažetak
The purpose of the current study is to uncover the impact of small liganded gold nanoclusters with 10 gold atoms and 10 glutathione ligands (Au10SG10) on several biomarkers in human microglia. We established the links connecting the atomically precise structure of Au10SG10 with their properties and changes in several biomolecules under oxidative stress. Au10SG10 caused the loss of mitochondrial metabolic activity, increased lipid peroxidation and translocation of an alarmin molecule, high mobility group box 1 (HMGB1), from the nucleus to the cytosol. Molecular modeling provided an insight into the location of amino acid interaction sites with Au10SG10 and the nature of bonds participating in these interactions. We show that Au10SG10 can bind directly to the defined sites of reduced, oxidized, and acetylated HMGB1. Further studies with similar complementary approaches merging live-cell analyses, determination of biomarkers, and cell functions could lead to optimized gold nanoclusters best suited for diagnostic and bioimaging purposes in neuroscience.

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA

Projekti:
EK-KF-KK.01.1.1.01.0003 - STIM-REI (STIM-REI) (Bonačić-Koutecky, Vlasta; Smital, Tvrtko; Orlić, Sandi, EK - KK.01.1.1.01) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Split,
Sveučilište u Splitu

Profili:

Avatar Url Martina Perić Bakulić (autor)

Avatar Url Vlasta Bonačić-Koutecky (autor)

Avatar Url Željka Sanader Maršić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Maysinger, Dusica; Sanader Maršić, Željka; Gran, Evan Rizzel; Shobo, Adeola; Macairan, Jun-Ray; Zhang, Issan; Perić Bakulić, Martina; Antoine, Rodolphe; Multhaup, Gerhard; Bonačić-Kouteckỳ, Vlasta
Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia // ACS Chemical Neuroscience, 13 (2022), 4; 464-476 doi:10.1021/acschemneuro.1c00621 (međunarodna recenzija, članak, znanstveni)
Maysinger, D., Sanader Maršić, Ž., Gran, E., Shobo, A., Macairan, J., Zhang, I., Perić Bakulić, M., Antoine, R., Multhaup, G. & Bonačić-Kouteckỳ, V. (2022) Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia. ACS Chemical Neuroscience, 13 (4), 464-476 doi:10.1021/acschemneuro.1c00621.
@article{article, author = {Maysinger, Dusica and Sanader Mar\v{s}i\'{c}, \v{Z}eljka and Gran, Evan Rizzel and Shobo, Adeola and Macairan, Jun-Ray and Zhang, Issan and Peri\'{c} Bakuli\'{c}, Martina and Antoine, Rodolphe and Multhaup, Gerhard and Bona\v{c}i\'{c}-Kouteckỳ, Vlasta}, year = {2022}, pages = {464-476}, DOI = {10.1021/acschemneuro.1c00621}, keywords = {gold nanocluster, microglia, HMGB1, cell death, lipid peroxidation, glutathione, oxidative stress, molecular modeling, QM/MM simulations}, journal = {ACS Chemical Neuroscience}, doi = {10.1021/acschemneuro.1c00621}, volume = {13}, number = {4}, issn = {1948-7193}, title = {Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia}, keyword = {gold nanocluster, microglia, HMGB1, cell death, lipid peroxidation, glutathione, oxidative stress, molecular modeling, QM/MM simulations} }
@article{article, author = {Maysinger, Dusica and Sanader Mar\v{s}i\'{c}, \v{Z}eljka and Gran, Evan Rizzel and Shobo, Adeola and Macairan, Jun-Ray and Zhang, Issan and Peri\'{c} Bakuli\'{c}, Martina and Antoine, Rodolphe and Multhaup, Gerhard and Bona\v{c}i\'{c}-Kouteckỳ, Vlasta}, year = {2022}, pages = {464-476}, DOI = {10.1021/acschemneuro.1c00621}, keywords = {gold nanocluster, microglia, HMGB1, cell death, lipid peroxidation, glutathione, oxidative stress, molecular modeling, QM/MM simulations}, journal = {ACS Chemical Neuroscience}, doi = {10.1021/acschemneuro.1c00621}, volume = {13}, number = {4}, issn = {1948-7193}, title = {Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia}, keyword = {gold nanocluster, microglia, HMGB1, cell death, lipid peroxidation, glutathione, oxidative stress, molecular modeling, QM/MM simulations} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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