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Pregled bibliografske jedinice broj: 1179522

Experimental and computational framework for a dynamic protein atlas of human cell division

Cai, Yin; Hossain, M. Julius; Hériché, Jean- Karim; Politi, Antonio Z.; Walther, Nike; Koch, Birgit; Wachsmuth, Malte; Nijmeijer, Bianca; Kueblbeck, Moritz; Martinic-Kavur, Marina et al.
Experimental and computational framework for a dynamic protein atlas of human cell division // Nature, 561 (2018), 7723; 411-415 doi:10.1038/s41586-018-0518-z (međunarodna recenzija, članak, znanstveni)

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Naslov
Experimental and computational framework for a dynamic protein atlas of human cell division

Autori
Cai, Yin ; Hossain, M. Julius ; Hériché, Jean- Karim ; Politi, Antonio Z. ; Walther, Nike ; Koch, Birgit ; Wachsmuth, Malte ; Nijmeijer, Bianca ; Kueblbeck, Moritz ; Martinic-Kavur, Marina ; Ladurner, Rene ; Alexander, Stephanie ; Peters, Jan-Michael ; Ellenberg, Jan

Izvornik
Nature (0028-0836) 561 (2018), 7723; 411-415

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mytosis ; cell division ; protein atlas ; mitotic protein ; mitosis progression ; protein localization ; fluorescence-correlation spectroscopy ; calibrated microscopy

Sažetak
Essential biological functions, such as mitosis, require tight coordination of hundreds of proteins in space and time. Localization, the timing of interactions and changes in cellular structure are all crucial to ensure the correct assembly, function and regulation of protein complexes1, 2, 3, 4. Imaging of live cells can reveal protein distributions and dynamics but experimental and theoretical challenges have prevented the collection of quantitative data, which are necessary for the formulation of a model of mitosis that comprehensively integrates information and enables the analysis of the dynamic interactions between the molecular parts of the mitotic machinery within changing cellular boundaries. Here we generate a canonical model of the morphological changes during the mitotic progression of human cells on the basis of four- dimensional image data. We use this model to integrate dynamic three-dimensional concentration data of many fluorescently knocked-in mitotic proteins, imaged by fluorescence correlation spectroscopy-calibrated microscopy5. The approach taken here to generate a dynamic protein atlas of human cell division is generic ; it can be applied to systematically map and mine dynamic protein localization networks that drive cell division in different cell types, and can be conceptually transferred to other cellular functions.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
GENOS d.o.o.

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Cai, Yin; Hossain, M. Julius; Hériché, Jean- Karim; Politi, Antonio Z.; Walther, Nike; Koch, Birgit; Wachsmuth, Malte; Nijmeijer, Bianca; Kueblbeck, Moritz; Martinic-Kavur, Marina et al.
Experimental and computational framework for a dynamic protein atlas of human cell division // Nature, 561 (2018), 7723; 411-415 doi:10.1038/s41586-018-0518-z (međunarodna recenzija, članak, znanstveni)
Cai, Y., Hossain, M., Hériché, J., Politi, A., Walther, N., Koch, B., Wachsmuth, M., Nijmeijer, B., Kueblbeck, M. & Martinic-Kavur, M. (2018) Experimental and computational framework for a dynamic protein atlas of human cell division. Nature, 561 (7723), 411-415 doi:10.1038/s41586-018-0518-z.
@article{article, author = {Cai, Yin and Hossain, M. Julius and H\'{e}rich\'{e}, Jean- Karim and Politi, Antonio Z. and Walther, Nike and Koch, Birgit and Wachsmuth, Malte and Nijmeijer, Bianca and Kueblbeck, Moritz and Martinic-Kavur, Marina and Ladurner, Rene and Alexander, Stephanie and Peters, Jan-Michael and Ellenberg, Jan}, year = {2018}, pages = {411-415}, DOI = {10.1038/s41586-018-0518-z}, keywords = {Mytosis, cell division, protein atlas, mitotic protein, mitosis progression, protein localization, fluorescence-correlation spectroscopy, calibrated microscopy}, journal = {Nature}, doi = {10.1038/s41586-018-0518-z}, volume = {561}, number = {7723}, issn = {0028-0836}, title = {Experimental and computational framework for a dynamic protein atlas of human cell division}, keyword = {Mytosis, cell division, protein atlas, mitotic protein, mitosis progression, protein localization, fluorescence-correlation spectroscopy, calibrated microscopy} }
@article{article, author = {Cai, Yin and Hossain, M. Julius and H\'{e}rich\'{e}, Jean- Karim and Politi, Antonio Z. and Walther, Nike and Koch, Birgit and Wachsmuth, Malte and Nijmeijer, Bianca and Kueblbeck, Moritz and Martinic-Kavur, Marina and Ladurner, Rene and Alexander, Stephanie and Peters, Jan-Michael and Ellenberg, Jan}, year = {2018}, pages = {411-415}, DOI = {10.1038/s41586-018-0518-z}, keywords = {Mytosis, cell division, protein atlas, mitotic protein, mitosis progression, protein localization, fluorescence-correlation spectroscopy, calibrated microscopy}, journal = {Nature}, doi = {10.1038/s41586-018-0518-z}, volume = {561}, number = {7723}, issn = {0028-0836}, title = {Experimental and computational framework for a dynamic protein atlas of human cell division}, keyword = {Mytosis, cell division, protein atlas, mitotic protein, mitosis progression, protein localization, fluorescence-correlation spectroscopy, calibrated microscopy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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