Naslov
Dokazi povezanosti šizofrenije i poremećaja izazvanih glutenskom prehranom
(Evidence for links between schizophrenia and gluten- related disorders)

Autori
Zuber, Lana Anet

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Odjel za biotehnologiju

Mjesto
Rijeka

Datum
16.09

Godina
2019

Stranica
24

Mentor
Bradshaw, Nicholas James

Ključne riječi
Poremećaji izazvani glutenskom prehranom ; Celijakija ; Šizofrenija ; Zonulin ; Gliadinski egzorfini ; Dipeptidil peptidaza IV (DPP IV)
(Gluten-related disorders ; Celiac disease ; Schizophrenia ; Zonulin ; Gliadin exorphins ; Dipeptidyl peptidase IV (DPP IV))

Sažetak
Gluten-related disorders affect all functional systems of the human body. So far more than twenty-five diseases and syndromes have been linked to gluten-related nutrition, including mental illnesses such as depression and anxiety. The main aim of this thesis was a review of literature linking schizophrenic symptoms, including schizophrenia itself, to a spectrum of gluten-related disorders. Because of the rarity of the target diseases, the main approach to linking the two are clinical cases and biological studies, through population-wide studies is not available. The human body is not capable of fully digesting gluten. In the process of partial break-down of gluten, gliadin exorphins are made. Individuals suffering from gluten-related disorders, if not on gluten-free diet, have increased permeability of the intestinal wall. This syndrome is also called Leaky gut syndrome. Increased permeability is caused by the protein zonulin whose levels increase after gluten ingestion in individuals suffering from gluten-related disorders. In healthy individuals this autoimmune reaction goes unnoticed or is not present. Symptoms following the reaction are chronic, and last, as long the gluten is present in the body what can be from couple of days to a couple of years. Most common symptoms are malnutrition, low energy levels, fatigue, bloating, stomach pains. This literature review focuses on gluten-related disorders with non-specific neurological symptoms such as depressive symptoms, hallucinations, apathy, lack of concentration, “foggy mind”, headaches, irritability, sleep abnormalities or behavioural alternations. A possible explanation behind those is the theory of gliadin exorphins, toxic peptides, that by passing through the body from the gastrointestinal tract to the brain are causing non-specific neurological symptoms. Even though there are some possible mechanisms explaining this neurological manifestation of gluten-related disorders, more research is needed to form definite conclusions.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA