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Pregled bibliografske jedinice broj: 1175049

Response and Outcomes to Immune Checkpoint Inhibitors in Advanced Urothelial Cancer Based on Prior Intravesical Bacillus Calmette-Guerin

Talukder, Rafee; Makrakis, Dimitrios; Diamantopoulos, Leonidas N; Carril-Ajuria, Lucia; Castellano , Daniel; De Kouchkovsky, Ivan; Koshkin, Vadim S; Park, Joseph J; Alva, Ajjai; Bilen, Mehmet A et al.
Response and Outcomes to Immune Checkpoint Inhibitors in Advanced Urothelial Cancer Based on Prior Intravesical Bacillus Calmette-Guerin // Clinical genitourinary cancer, 19 (2021), 6; 31-35 doi:10.1016/j.clgc.2021.12.012 (međunarodna recenzija, članak, stručni)

CROSBI ID: 1175049 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Response and Outcomes to Immune Checkpoint Inhibitors in Advanced Urothelial Cancer Based on Prior Intravesical Bacillus Calmette-Guerin

Autori
Talukder, Rafee ; Makrakis, Dimitrios ; Diamantopoulos, Leonidas N ; Carril-Ajuria, Lucia ; Castellano , Daniel ; De Kouchkovsky, Ivan ; Koshkin, Vadim S ; Park, Joseph J ; Alva, Ajjai ; Bilen, Mehmet A ; Stewart, Tyler F ; McKay, Rana R ; Santos, Victor S ; Agarwal, Neeraj ; Jain, Jayanshu ; Zakharia, Yousef ; Morales-Barrera, Rafael ; Devitt, Michael E ; Grant, Michael ; Lythgoe, Mark P ; Pinato, David J ; Nelson, Ariel ; Hoimes, Christopher J ; Shreck, Evan ; Gartrell, Benjamin A ; Sankin, Alex ; Tripathi, Abhishek ; Zakopoulou, Roubini ; Bamias, Aristotelis ; Murgić, Jure ; Fröbe, Ana ; Rodriguez- Vida, Alejo ; Drakaki, Alexandra ; Liu, Sandy ; Kumar, Vivek ; Di Lorenzo, Giuseppe ; Joshi, Monika ; Isaacsson Velho, Pedro ; Alonso Buznego, Lucia ; Duran, Ignacio ; Moses, Marcus ; Barata, Pedro ; Sonpavde, Guru ; Yu, Evan Y ; Wright, Jonathan L ; Grivas, Petros ; Khaki, Ali Raza.

Izvornik
Clinical genitourinary cancer (1558-7673) 19 (2021), 6; 31-35

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
BCG ; bladder cancer ; immunotherapy ; outcomes ; urinary tract neoplasms

Sažetak
Background: Immune checkpoint inhibitors (ICI) improve overall survival (OS) in patients with locally advanced, unresectable, or metastatic urothelial carcinoma (aUC), but response rates can be modest. We compared outcomes between patients with and without prior intravesical Bacillus Calmette-Guerin (BCG), who received ICI for aUC, hypothesizing that prior intravesical BCG would be associated with worse outcomes. Patients and methods: We performed a retrospective cohort study across 25 institutions in US and Europe. We compared observed response rate (ORR) using logistic regression ; progression-free survival (PFS) and OS using Kaplan-Meier and Cox proportional hazards. Analyses were stratified by treatment line (first line/salvage) and included multivariable models adjusting for known prognostic factors. Results: A total of 1026 patients with aUC were identified ; 614, 617, and 638 were included in ORR, OS, PFS analyses, respectively. Overall, 150 pts had history of prior intravesical BCG treatment. ORR to ICI was similar between those with and without prior intravesical BCG exposure in both first line and salvage settings (adjusted odds radios 0.55 [P= .08] and 1.65 [P= .12]). OS (adjusted hazard ratios 1.05 [P= .79] and 1.13 [P= .49]) and PFS (adjusted hazard ratios 1.12 [P= .55] and 0.87 [P= .39]) were similar between those with and without intravesical BCG exposure in first line and salvage settings. Conclusion: Prior intravesical BCG was not associated with differences in response and survival in patients with aUC treated with ICI. Limitations include retrospective nature, lack of randomization, presence of selection and confounding biases. This study provides important preliminary data that prior intravesical BCG exposure may not impact ICI efficacy in aUC.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Ustanove:
Stomatološki fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Ana Fröbe (autor)

Avatar Url Jure Murgić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Talukder, Rafee; Makrakis, Dimitrios; Diamantopoulos, Leonidas N; Carril-Ajuria, Lucia; Castellano , Daniel; De Kouchkovsky, Ivan; Koshkin, Vadim S; Park, Joseph J; Alva, Ajjai; Bilen, Mehmet A et al.
Response and Outcomes to Immune Checkpoint Inhibitors in Advanced Urothelial Cancer Based on Prior Intravesical Bacillus Calmette-Guerin // Clinical genitourinary cancer, 19 (2021), 6; 31-35 doi:10.1016/j.clgc.2021.12.012 (međunarodna recenzija, članak, stručni)
Talukder, R., Makrakis, D., Diamantopoulos, L., Carril-Ajuria, L., Castellano , D., De Kouchkovsky, I., Koshkin, V., Park, J., Alva, A. & Bilen, M. (2021) Response and Outcomes to Immune Checkpoint Inhibitors in Advanced Urothelial Cancer Based on Prior Intravesical Bacillus Calmette-Guerin. Clinical genitourinary cancer, 19 (6), 31-35 doi:10.1016/j.clgc.2021.12.012.
@article{article, author = {Talukder, Rafee and Makrakis, Dimitrios and Diamantopoulos, Leonidas N and Carril-Ajuria, Lucia and Castellano, Daniel and De Kouchkovsky, Ivan and Koshkin, Vadim S and Park, Joseph J and Alva, Ajjai and Bilen, Mehmet A and Stewart, Tyler F and McKay, Rana R and Santos, Victor S and Agarwal, Neeraj and Jain, Jayanshu and Zakharia, Yousef and Morales-Barrera, Rafael and Devitt, Michael E and Grant, Michael and Lythgoe, Mark P and Pinato, David J and Nelson, Ariel and Hoimes, Christopher J and Shreck, Evan and Gartrell, Benjamin A and Sankin, Alex and Tripathi, Abhishek and Zakopoulou, Roubini and Bamias, Aristotelis and Murgi\'{c}, Jure and Fr\"{o}be, Ana and Rodriguez- Vida, Alejo and Drakaki, Alexandra and Liu, Sandy and Kumar, Vivek and Di Lorenzo, Giuseppe and Joshi, Monika and Isaacsson Velho, Pedro and Alonso Buznego, Lucia and Duran, Ignacio and Moses, Marcus and Barata, Pedro and Sonpavde, Guru and Yu, Evan Y and Wright, Jonathan L and Grivas, Petros and Khaki, Ali Raza.}, year = {2021}, pages = {31-35}, DOI = {10.1016/j.clgc.2021.12.012}, keywords = {BCG, bladder cancer, immunotherapy, outcomes, urinary tract neoplasms}, journal = {Clinical genitourinary cancer}, doi = {10.1016/j.clgc.2021.12.012}, volume = {19}, number = {6}, issn = {1558-7673}, title = {Response and Outcomes to Immune Checkpoint Inhibitors in Advanced Urothelial Cancer Based on Prior Intravesical Bacillus Calmette-Guerin}, keyword = {BCG, bladder cancer, immunotherapy, outcomes, urinary tract neoplasms} }
@article{article, author = {Talukder, Rafee and Makrakis, Dimitrios and Diamantopoulos, Leonidas N and Carril-Ajuria, Lucia and Castellano, Daniel and De Kouchkovsky, Ivan and Koshkin, Vadim S and Park, Joseph J and Alva, Ajjai and Bilen, Mehmet A and Stewart, Tyler F and McKay, Rana R and Santos, Victor S and Agarwal, Neeraj and Jain, Jayanshu and Zakharia, Yousef and Morales-Barrera, Rafael and Devitt, Michael E and Grant, Michael and Lythgoe, Mark P and Pinato, David J and Nelson, Ariel and Hoimes, Christopher J and Shreck, Evan and Gartrell, Benjamin A and Sankin, Alex and Tripathi, Abhishek and Zakopoulou, Roubini and Bamias, Aristotelis and Murgi\'{c}, Jure and Fr\"{o}be, Ana and Rodriguez- Vida, Alejo and Drakaki, Alexandra and Liu, Sandy and Kumar, Vivek and Di Lorenzo, Giuseppe and Joshi, Monika and Isaacsson Velho, Pedro and Alonso Buznego, Lucia and Duran, Ignacio and Moses, Marcus and Barata, Pedro and Sonpavde, Guru and Yu, Evan Y and Wright, Jonathan L and Grivas, Petros and Khaki, Ali Raza.}, year = {2021}, pages = {31-35}, DOI = {10.1016/j.clgc.2021.12.012}, keywords = {BCG, bladder cancer, immunotherapy, outcomes, urinary tract neoplasms}, journal = {Clinical genitourinary cancer}, doi = {10.1016/j.clgc.2021.12.012}, volume = {19}, number = {6}, issn = {1558-7673}, title = {Response and Outcomes to Immune Checkpoint Inhibitors in Advanced Urothelial Cancer Based on Prior Intravesical Bacillus Calmette-Guerin}, keyword = {BCG, bladder cancer, immunotherapy, outcomes, urinary tract neoplasms} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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