Naslov
Minimalistic Peptide-based Virus Mimetics

Autori
Janković, Patrizia ; Budić, Katarina ; Pina, Ana Sofia ; Kalafatovic, Daniela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Systems Chemistry Symposium

Mjesto i datum
Online, 07.07.2021. - 09.07.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
self-assembly, viral mimetics, peptides, minimalistic, co-assembly

Sažetak
As a global pandemic is endangering our health system, there is a need for novel therapeutic and diagnostic tools. Peptide nanomaterials have emerged as a possible solution as they are able to mimic the viral morphology and/or functionality through self-assembly. We have analyzed the SARS- CoV-2 spike (S) protein interaction with the ACE2 and NRP1 receptors that enable viral entry into cells and designed three amphiphilic peptide sequences derived from the S-protein receptor binding domain (RBD)1, 2. Herein we show the results for only one, FFLYYKK. The design was based on the idea that such peptides can self- assemble into higher order spherical aggregates resembling the supramolecular architecture of SARS-CoV-2 and therefore used as safe platforms to study viral infections. ​

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA