Pregled bibliografske jedinice broj: 1174625
Considering precision medicine in the setting of systemic disease – missing puzzles
Considering precision medicine in the setting of systemic disease – missing puzzles // ISPCM Annual Meeting 2018 / Yong Sang, Song (ur.).
Seoul: Blue Cloud, 2018. str. 56-57 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1174625 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Considering precision medicine in the setting of
systemic disease – missing puzzles
Autori
Gall Trošelj, Koraljka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
ISPCM Annual Meeting 2018
/ Yong Sang, Song - Seoul : Blue Cloud, 2018, 56-57
Skup
ISPCM Annual Meeting 2018
Mjesto i datum
Busan, Republika Koreja, 15.03.2018. - 19.03.2018
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
precision medicine ; cancer ; reprogramming of energy metabolism
Sažetak
Understanding cancer biology in 21st century is still a very difficult task. While clinical medicine needs to find ways for dealing with this disease at many levels, molecular medicine has been mostly focused on mutational analyses extending to research related to transcriptome/proteome/ interactome studies. All these efforts have been concentrated on discovering early diagnostic markers and improving disease treatment. In 2011, two hallmarks of cancer: reprogramming of energy metabolism and evading immune destruction were added to the previous six hallmarks, which were proposed by Hanahan and Weinberg in 2000. Currently, the cancer’s cell metabolism and its “hiding” from the host’s immunological system, tend to be the basis for understanding the pathophysiology of seemingly unrelated signs of systemic disturbance which we diagnose as “cancer”. Several top-quality papers published in 2016/2017 strongly shed new light on an old hypothesis, officially suggested back in 1931, that cancer may represent a systemic disease. This new data must be considered in the setting of the human microbiome. Not understanding all its roles and functions, especially those related to the existence and/or absence of specific metabolites, may be an important gap in elucidating the most important aspects of cancer. Some of these issues, which should be viewed as “missing puzzles”, will be explained and carefully discussed.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
