Naslov
Varijante gena za progesteronski receptor u trudnica i fetusa kao mogući prediktori spontanog prijevremenog poroda
(Progesterone receptor genetic variants in pregnant women and fetuses as possible predictors of spontaneous premature birth)

Autori
Kadivnik, Mirta ; Kralik, Kristina ; WAgner, Jasenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts of 14° Congress of the European Society of Gynecology / - , 2021, 48-49

Skup
14th Congress of the European Society of Gynecology

Mjesto i datum
Venecija, Italija, 10.11.2021. - 13.11.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
premature birth ; progegesterone ; progesterone receptors, single nucleotyde polymorphisms
(prijevremeni porod, progesteron, progesteronski receptori, polimorfizam jednog nukleotida)

Sažetak
Premature birth (PTB) is defined as a live birth before 37 weeks of gestation. Besides its association with mortality, there are both acute and chronic morbidities associated with PTB, including long-term sequelae such as cognitive and motor delays. One of the recognized risk factors for PTB is a maternal and/or fetal genetic predispositio. One of main pathways involved in uterine quiescence is progesterone (P4) pathway. A number of single nucleotide polymorphisms (SNPs) have been described in human PGR.The aim of this study was to evaluate the roles of four selected genetic variations in fetal and maternal progesterone receptor gene (PGR) and to identify women who may have higher or lower odds for PTB compared to the general population.

Izvorni jezik
Engleski

POVEZANOST RADA