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Pregled bibliografske jedinice broj: 1173631

Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

Franjic, Daniel; Skarica, Mario; Ma, Shaojie; Arellano, Jon I.; Tebbenkamp, Andrew T.N.; Choi, Jinmyung; Xu, Chuan; Li, Qian; Morozov, Yury M.; Andrijevic, David et al.
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells // Neuron, (2021), 110; 1-18 doi:10.1016/j.neuron.2021.10.036 (međunarodna recenzija, članak, znanstveni)

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Naslov
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

Autori
Franjic, Daniel ; Skarica, Mario ; Ma, Shaojie ; Arellano, Jon I. ; Tebbenkamp, Andrew T.N. ; Choi, Jinmyung ; Xu, Chuan ; Li, Qian ; Morozov, Yury M. ; Andrijevic, David ; Vrselja, Zvonimir ; Spajic, Ana ; Santpere, Gabriel ; Li, Mingfeng ; Zhang, Shupei ; Liu, Yang ; Spurrier, Joshua ; Zhang, Le ; Gudelj, Ivan ; Rapan, Lucija ; Takahashi, Hideyuki ; Huttner, Anita ; Fan, Rong ; Strittmatter, Stephen M. ; Sousa, Andre M.M. ; Rakic, Pasko ; Sestan, Nenad

Izvornik
Neuron (0896-6273) (2021), 110; 1-18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adult neurogenesis ; Alzheimer's disease ; doublecortin ; entorhinal cortex ; evolution ; hippocampus ; immature neurons ; METTL7B ; neuroblast ; single-cell RNA-seq

Sažetak
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To investigate neurogenic potential and cellular diversity, we profiled single-nucleus transcriptomes in five hippocampal-entorhinal subregions in humans, macaques, and pigs. Integrated cross-species analysis revealed robust transcriptomic and histologic signatures of neurogenesis in the adult mouse, pig, and macaque but not humans. Doublecortin (DCX), a widely accepted marker of newly generated granule cells, was detected in diverse human neurons, but it did not define immature neuron populations. To explore species differences in cellular diversity and implications for disease, we characterized subregion-specific, transcriptomically defined cell types and transitional changes from the three-layered archicortex to the six-layered neocortex. Notably, METTL7B defined subregion-specific excitatory neurons and astrocytes in primates, associated with endoplasmic reticulum and lipid droplet proteins, including Alzheimer's disease-related proteins. This resource reveals cell-type- and species-specific properties shaping hippocampal- entorhinal neurogenesis and function.

Izvorni jezik
Engleski



POVEZANOST RADA

Profili:

Avatar Url Ivan Gudelj (autor)

Avatar Url Mario Škarica (autor)

Avatar Url Zvonimir Vrselja (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Franjic, Daniel; Skarica, Mario; Ma, Shaojie; Arellano, Jon I.; Tebbenkamp, Andrew T.N.; Choi, Jinmyung; Xu, Chuan; Li, Qian; Morozov, Yury M.; Andrijevic, David et al.
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells // Neuron, (2021), 110; 1-18 doi:10.1016/j.neuron.2021.10.036 (međunarodna recenzija, članak, znanstveni)
Franjic, D., Skarica, M., Ma, S., Arellano, J., Tebbenkamp, A., Choi, J., Xu, C., Li, Q., Morozov, Y. & Andrijevic, D. (2021) Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron, (110), 1-18 doi:10.1016/j.neuron.2021.10.036.
@article{article, author = {Franjic, Daniel and Skarica, Mario and Ma, Shaojie and Arellano, Jon I. and Tebbenkamp, Andrew T.N. and Choi, Jinmyung and Xu, Chuan and Li, Qian and Morozov, Yury M. and Andrijevic, David and Vrselja, Zvonimir and Spajic, Ana and Santpere, Gabriel and Li, Mingfeng and Zhang, Shupei and Liu, Yang and Spurrier, Joshua and Zhang, Le and Gudelj, Ivan and Rapan, Lucija and Takahashi, Hideyuki and Huttner, Anita and Fan, Rong and Strittmatter, Stephen M. and Sousa, Andre M.M. and Rakic, Pasko and Sestan, Nenad}, year = {2021}, pages = {1-18}, DOI = {10.1016/j.neuron.2021.10.036}, keywords = {adult neurogenesis, Alzheimer's disease, doublecortin, entorhinal cortex, evolution, hippocampus, immature neurons, METTL7B, neuroblast, single-cell RNA-seq}, journal = {Neuron}, doi = {10.1016/j.neuron.2021.10.036}, number = {110}, issn = {0896-6273}, title = {Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells}, keyword = {adult neurogenesis, Alzheimer's disease, doublecortin, entorhinal cortex, evolution, hippocampus, immature neurons, METTL7B, neuroblast, single-cell RNA-seq} }
@article{article, author = {Franjic, Daniel and Skarica, Mario and Ma, Shaojie and Arellano, Jon I. and Tebbenkamp, Andrew T.N. and Choi, Jinmyung and Xu, Chuan and Li, Qian and Morozov, Yury M. and Andrijevic, David and Vrselja, Zvonimir and Spajic, Ana and Santpere, Gabriel and Li, Mingfeng and Zhang, Shupei and Liu, Yang and Spurrier, Joshua and Zhang, Le and Gudelj, Ivan and Rapan, Lucija and Takahashi, Hideyuki and Huttner, Anita and Fan, Rong and Strittmatter, Stephen M. and Sousa, Andre M.M. and Rakic, Pasko and Sestan, Nenad}, year = {2021}, pages = {1-18}, DOI = {10.1016/j.neuron.2021.10.036}, keywords = {adult neurogenesis, Alzheimer's disease, doublecortin, entorhinal cortex, evolution, hippocampus, immature neurons, METTL7B, neuroblast, single-cell RNA-seq}, journal = {Neuron}, doi = {10.1016/j.neuron.2021.10.036}, number = {110}, issn = {0896-6273}, title = {Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells}, keyword = {adult neurogenesis, Alzheimer's disease, doublecortin, entorhinal cortex, evolution, hippocampus, immature neurons, METTL7B, neuroblast, single-cell RNA-seq} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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