Naslov
Platelets – cells with many functions

Autori
Karla Soldatić

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, preddiplomski

Fakultet
Odjel za biotehnologiju

Mjesto
Rijeka

Datum
28.07

Godina
2021

Stranica
48

Mentor
Antonija Jurak Begonja

Ključne riječi
Trombociti ; hemostaza ; tromboza ; imunitet ; upala ; tumor ; antitrombocitna terapija
(Platelets ; haemostasis ; thrombosis ; immunity ; inflammation ; tumour ; antiplatelet therapies)

Sažetak
Platelets are the second most abundant type of blood cells. The range of their functions is wide, but they are best known for their role in haemostasis. Through delicate mechanisms of activation, adhesion and aggregation, platelets successfully repair endothelial injuries, thus stopping bleeding. There are mechanisms in place which regulate activation and inhibition of platelets depending on the stimuli received from their surroundings. When these mechanisms are impaired and out of balance, there is a high chance of haemostatic events evolving into thrombotic ones. Thrombosis can lead to a plethora of disease conditions, some of which are the leading causes of death in the world, and the need for their treatment is, therefore, of great significance. This paper will discuss the various complex roles of platelets which prove them to be a crucial cell in haemostatic and non-haemostatic events. Platelets are found at the interface of inflammatory diseases and tumour formation, and their specific roles in these will be discussed in detail. Furthermore, while they have a protective role in immunity, some viruses are able to spread their infection by using platelets as accomplices. Additionally, this paper will also show the potential platelets hold as targets in treating several diseases and conditions. Finally, all the pathways which allow platelets to become activated and serve in haemostasis, also allow for their contribution in development of thrombosis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA