Naslov
Cell proliferation and p53 protein expression in proliferative skin diseases

Autori
Tanja, Batinac ; Zamolo, Gordana ; Gruber, Franjo ; Lipozenčić, Jasna ; Jonjić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
14th Ljudevit Jurak International Symposium on Comparative pathology, June 6-7. 2003, Zagreb, Croatia / - Zagreb, 2003

Skup
14th Ljudevit Jurak International Symposium on Comparative pathology, June 6-7. 2003, Zagreb,

Mjesto i datum
Zagreb, Hrvatska, 06.06.2003. - 07.06.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
p53 tumor suppressor protein; Ki-67 protein; non-malignant and malignant skin diseases

Sažetak
Aim of the study is to elucidate the role of the p53 tumor-suppressor protein in the pathogenesis of different hyperproliferative, non-malignant and malignant skin diseases and association between p53 overexpression and cell proliferation. We also investigated the influence of aging on p53 and Ki-67 protein expression. Methods: Hundred and fifty skin specimens, consisting 30 cases of each, normal skin (NS), psoriatic skin (PS), keratoacanthomas (KA), basal cell carcinomas (BCC), squamous cell carcinomas (SCC) were examined immunohistochemicaly to assess p53 and Ki-67 protein expression. Results: P53 immunostaining of NS, PS, KA, BCC and SCC was positive in 39.0%, 46.7%, 66.7%, 80% and 86.7% cases, respectively. P53 and Ki-67 positive cells were present in basal (NS) and suprabasal layers (PS), and not only in cancer nests of KA, BCC and SCC, but also in dysplastic and even morphologically normal epidermis adjoining cancers. The positivity of p53 and Ki-67 protein differed significantly among the groups with no differences in p53 expression between NS and PS, and in Ki-67 expression between PS and KA. Within all groups, there was a significant correlation between p53 and Ki-67 expression.Conclusion: Our findings suggest that p53 overexprression occurs widely in neoplastic and non-neoplastic skin lesions. It is associated with the cell proliferation in normal, as well as, in changed epithelium. P53 accumulation is an age related process and significantly related to sun exposure, especially in NS and PS as well as in KA and SCC. We also duggest that p53 everexpression begins in the early stage of carcinogenesis, before the appearance of malignancies in skin, and may be a useful predictor for the detection of nonmelanocytic skin cancer.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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