Naslov
Increased platelet-associated immunoglobulins are common feature of chronic immune thrombocytopenic purpura only in later stages of the disease

Autori
Ivanković, Zdravko ; Gojčeta, Koraljka ; Lukić, Marija ; Plenković, Fini ; Bojanić, Ines ; Labar, Boris ; Golubić Ćepulić, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
27th Congress of the International Society of Blood Transfusion

Mjesto i datum
Vancouver, Kanada, 24.-29.8

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
platelet-associated immunoglobulins, thrombocytopenic purpura

Sažetak
Objective. Assessment of predictive values of PA- IgG test indifferent stages of chronic ITP Design. PA-IgG tests were performed by adapted Thrombo match EIA (Biotest, Germany) in adult patients with chronic ITP of different stages, as well as in patients with presumably non-immune thrombocytopenias. All tests were performed in duplicate. Results exceeding negative control reading+3 standard deviations were considered positive. Materials. PA-IgG tests were performed in 26"early"«6months)and 18"late"(>6 moths after diagnosis) patients with chronic ITP. Control groupconsistedof13thrombocytopenicpatients with myeloid diseases, 7 with solid malignant tumors, 5 with chronic liver disease and 19non- thrombocytopenicpatients suffering from vascular cerebral diseases. Conclusion. Increased PA-IgG seems to be less pronounced feature in early than in later phases of chronic ITP in adults. The consequences of this feature may be impaired validity of PA-IgG tests when performed shortly following clinical diagnosis, but also a hint that first months of chronic ITP may be characterized with some distinct pathophysiologic features.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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