Naslov
Changes in techniques of RBC antibody detection and incidence of delayed transfusion reactions

Autori
Plenković, Fini ; Bojanić, Ines ; Ivanković, Zdravko ; Lukić, Marija ; Golubić Ćepulić, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
28th Congress of International Society of Blood Transfusion

Mjesto i datum
Edinburgh, Ujedinjeno Kraljevstvo, 11.-15.7

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
techniques of RBC antibody detection, delayed transfusion reactions

Sažetak
New sensitive techniques for RBC antibody detection might result in an increase ofincidence of delayed hemolytic transfusion reactions (DHTRs) and delayed serologictransfusion reactions (DSTRs). Because of bloodgrouping automatisation at ClinicalHospital Centre, Ortho column agglutination test (CAT) replaced the tube test (TT) in1998. In 2000, DiaMed gel test (GT) replaced the TT in crossmatching, too. DHTR andDSTR data from 1998 to 1999 and data from 2000 to 2002 were reviewed. These datawere compared with our historical data (1990–1997) when TT was used. Withintroduction of micromethods in pretransfusion testing, we observed evident increaseof total incidence of both DHTRs and DSTRs, from 1:4347 to 1:2000 (P< 0.001). Theincidence of DHTR was almost the same, but the incidence of DSTR increased from1:8333 to 1:2500 (P< 0.000001) units transfused. The introduction of GT incrossmatching resulted in another increase of total incidence of DHTR/DSTRs, from1:4167 to 1:1389 (P< 0.001) compared with period when CAT was used only onbloodgrouping. The incidence of DHTR did not significantly change but the incidenceof DSTR increased from 1:5556 to 1:1754 (P< 0.001). 122 RBC antibodies involved inappearance of DHTR/DSTRs, represent 6.9% of totally discovered clinically significantalloantibodies in evaluated periods

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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